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Biomedical subjects

P K Upton

Publications and source records attributed to P K Upton.

16 recordsLinked to original sources
PubMed1977

Effects of chronic hydrochloric and lactic acid administrations on food intake, blood acid-base balance and bone composition of the rat.

In experiment 1, weanling rats were given, for 7 weeks, a commercial rat diet supplemented with hydrochloric acid at levels up to 560 mmol.kg-1 dry matter. The supplement increased water intake but did not significantly affect food intake, live-weight gain, blood haemoglobin and haematocrit values or acid-base balance. In experiment 2, adult rats were given, for 9 weeks, a commercial rat diet supplemented with hydrochloric acid at levels up to 1250 mmol.kg-1 dry matter. Food intake and liveweight gain were not affected by hydrochloric acid concentration up to 625 mmole but at 938 mmol.kg-1 they were considerably reduced and there was 100% mortality of the rats. In experiment 3, weanling rats were given, for 12 weeks, a commercial rat diet supplemented with hydrochloric or lactic acid each at 300, 600 and 900 mmol.kg-1 dry matter. Lactic acid at the three levels and hydrochloric acid at the two lower levels did not affect food intake or live weight gain and had only a slight effect on blood acid-base balance. At a dietary concentration of 900 mmol.kg-1 dry matter, hydrochloric acid decreased food intake, induced a mild degree of metabolic acidosis and resulted in 30% mortality of the rats. In the three experiments, the acid treatments dnot directly affect the length or composition of the femur of the rats.

Acid-Base Equilibrium↗
PubMed1975

The effect of sampling technique on some blood parameters in the rat.

When used to restrain rats while obtaining cardiac blood, there was little difference between the effects of ether, pentobarbitone sodium, and fentanyl plus droperidol on acid-base balance, haemoglobin, haematocrit, plasma protein, calcium and magnesium. The use of manual restraint increased blood acidity, plasma protein, calcium and magnesium, but decreased blood glucose. Haemoglobin and haematocrit values were higher for tail blood than for blood removed from the heart or abdominal aorta.

Anesthesia↗
PubMed1975

The effect of sampling technique on acid-base balance and other blood parameters in the sheep.

The effect of 4 sampling routines--venipuncture, intravenous cannula, intravenous cannula following the administration of a tranquiliser (xylidino dihydrothiazine hydrochloride), intravenous cannula following exercise--were compared. Blood pH and base excess values were similar after venipuncture and cannula sampling, but higher (P less than 0 with 05) after the administration of the tranquiliser and lower (P less than 3 with 05) following exercise. Blood haemoglobin, haematocrit and lactate levels followed this pattern, while plasma protein levels were similar for all treatments except after exercise, where they were higher (P less than 0 with 05). The recovery of various blood parameters to normal values after a period of exercise was also studied: acid-base balance had returned to near normal within 60 min, while haemoglobin and haematocrit levels had returned to normal within 10 min.

Acid-Base Equilibrium↗