Snuff and recurring pulmonary infiltrations in chronic renal failure.
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Biomedical subjects
Publications and source records attributed to P König.
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Two groups of patients (nine patients each) were treated for acute alcaloid-withdrawal-syndromes. One group was given peroral neuroleptic medication, the other was treated by neuroleptic cocktail administered via vena subclavia catheter. By statistic comparison of the two methods the superiority of the latter could be shown in that duration of withdrawal, the syndrome itself and hallucinatory transitional psychoses could be drastically reduced. A suitable prescription and dosages of the neuroleptic cocktail are presented. The results are compared to the ones in current literature.
A case is presented of lithium intoxication with therapeutic doses of lithium, owing to the additional administration of a sodium-excreting diuretic. Since the patient was receiving neuroleptic therapy at the same time, intoxication symptoms at the onset were falsely attributed to neuroleptic extrapyramidal effects. The possible effects of widely-used diuretics in conjunction with lithium therapy are presented. The combination of both therapeutic substances is possible, but calls for extreme caution and strict control of medication, diet and serum lithium levels.
The effect of prolonged salbutamol administration on beta-adrenoceptor function in asthma has been examined. Six adult patients received salbutamol tablets (16 mg daily) for between 4 and 20 weeks and six adolescents received salbutamol aerosol (800 microgram daily) for 2--5 weeks. Before and after the treatment period the acute bronchodilator response to inhaled salbutamol and the ability of inhaled salbutamol to protect against exercise-induced asthma were examined. Lymphocyte beta-adrenoceptor function was also measured in the patients on tablet therapy. Inhaled salbutamol was less effective in protecting against exercise-induced asthma at the end of the treatment period in the patients who had received tablet therapy, but otherwise there was no significant change in beta-receptor function of either airways or lymphocytes. This apparent loss of efficacy of inhaled salbutamol in the prevention of exercise-induced asthma in some subjects, even when its acute bronchodilator effect is preserved, might reflect differences in the susceptibility of different beta-adrenoceptors to desensitization after prolonged stimulation: its clinical importance remains uncertain.
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Based on cases of a Psychiatric Intensive Care Unit specific indications and applications of catheterism of central-veins in these special instances are presented, the psychiatric indications and contraindications for such measures are submitted in addition to those known from other medical fields. The mode of insertion, duration, infusionregimen and rates of complications are reviewed in 102 cases. Two of the common veinous-catheter systems are compared as for practicability.
Selective B2 adrenergic agents given by nebulizer is described as a hospital or office treatment for severe attacks of asthma. Salbutamol and Bronkosol are shown to be effective and safe drugs. The method is a simple alternative to IPPB and is easier to use in small children. The use of long-acting, selective B2 adrenergic drugs by nebulizer is recommended in preference to non-selective and short-acting adrenergic agents like epinephrine and isoproterenol.
In 241 outpatients with asthma a higher prevalence of croup (33.2%) was found than in 131 controls (20.6%). The difference for recurrent croup was even more significant. Among inpatients with croup, compared with controls without, a greater tendency towards asthma, but not towards other atopic diseases, was found.
The insertion of a central venous catheter in the treatment of psychiatric patients is discussed on the basis of the therapeutic results obtained in 102 cases admitted to a psychiatric intensive care unit. Psychiatric indications and contraindications are now added to the known general indications and contraindications under other circumstances. Hypercaloric solutions, insertion technique into the subclavian and external jugular veins, duration of catether-aided nutrition and incidence of complications are discussed. The groups of psychiatric patients in whom the diagnosis is likely to lead to catheterization are defined. Two well-known catheter systems are discussed.
The anticonvulsive action of taurine, was tested in 9 therapy in 9 therapy-resistant patients with a high incidence of seizures. Taurine was given orally (1.5-7.5 g daily) over a period of 4 to 16 weeks and, despite the high dosage, no appreciable side effects were observed. During this time seizures disappeared temporarily for about two weeks in 5 out of 9 cases. In one case the seizure frequency was transiently reduced by approximately 25%, whilst in the remaining 3 cases no effect of taurine on seizure frequency was observed. The reason for the rapid disappearance of the anticonvulsive action of taurine is not known.
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