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Biomedical subjects

P Karsenti

Publications and source records attributed to P Karsenti.

At least 19 recordsLinked to original sources
PubMed1985

[Granulopoiesis in the alcoholic and cirrhotic patient. Exploration of neutropenia in cirrhosis using bone marrow cultures and a hydrocortisone test].

Twenty per cent of 60 patients with cirrhosis (55 alcoholic patients) had neutropenia (defined as neutrophil polymorphonuclear (NP) count under 2,000/mm3). The authors tried to define the mechanism of this neutropenia and compared it with the acute bone marrow cytotoxicity of alcohol. They found that bone marrow neutrophil colony growth was normal in 7 cases of cirrhosis compared to 7 controls (with and without cirrhotic serum incubation). On the other hand, the granulocyte response to hydrocortisone test was less marked than in controls. This result suggests involvement of the late maturation process of NP and delayed release from bone marrow.

Agranulocytosis↗
PubMed1983

[Pharmacokinetics of gentamicin in the decompensed alcoholic cirrhotic patient. Therapeutic consequences].

Aminoglycosides and in particular gentamicin are still largely used in the treatment of spontaneous bacterial peritonitis in the decompensed alcoholic cirrhotic patient. For that matter, we decided to study the various passage of gentamicin in the ascites after its administration through IM injection (80 mg in 6 patients and 120 mg in 6 other patients) and through IV injection (120 mg in 6 other patients). What could possibly be the best protocol to replace the daily intraperitoneal injections? We found out that no matter what the style of injection is, the peritoneal levels are only exceptionnaly higher than 3 mg/g at the highest peak period. These results brought us to analyze the passage of gentamicin in the blood when injected intraperitonealy (160 mg in 6 patients), and then to propose a therapeutic protocol combining on the first day, to the peritoneal injection a loading dose of an IP injection of 160 mg, the relay been taken over later with a peritoneal injection of 80 or 120 mg repeated 2 or 3 times daily. For each of the protocol the pharmacokinetic coefficients of gentamicin were calculated.

Bacterial Infections↗
PubMed1980

[Cirrhosis of the liver and "lymphomas": five new cases (author's transl)].

Five patients who manifested an association between chronic liver disease and lymphoma are reported by the authors. Lymphoma developed long after the presence of liver disease or was discovered simultaneously in the five cases. A review of the available literature yielded a total of thirteen similar cases. Several mechanisms may be operative in the pathogenesis of this association: presence of HBs Ag, chronic antigenic stimulation, decrease in cellular immunity, and immunosuppressive therapy.

Adult↗
PubMed1979

[Extensive bronchial dystrophy. Physiopathology and treatment of suppurative complications (author's transl)].

Extensive bronchial dystrophy differs by its histopathology, course and treatment from chronic obstructive bronchitis. This dystrophy leads to cavities which are virtually constantly infected. The extension of infection to adjacent alveoli may be dramatic, contrasting with underlying slight chronic respiratory failure. The existence of these cavities explains the preponderant role in therapy of drainage and the fact that antibiotic therapy would appear to be indicated only in the case of extension of infection to the alveoli and the peribronchial tissues.

Anti-Bacterial Agents↗