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Biomedical subjects

P Kechijian

Publications and source records attributed to P Kechijian.

At least 19 recordsLinked to original sources
PubMed1991

Nail polish removers: are they harmful?

An 11-year-old girl developed blisters on her fingers after wiping up spilled nail polish remover. This reaction and other adverse effects and hazards of polish removers are reviewed. In addition to blister formation, polish removers may cause irritant and allergic contact dermatitis, onycholysis, paronychia, and brittleness. They represent a fire hazard and may cause systemic toxicity following excessive inhalation.

Acetates↗
PubMed1989

Longitudinal melanonychia (melanonychia striata): diagnosis and management.

Longitudinal melanonychia presents a difficult clinical challenge because subungual melanoma must always be included in the differential diagnosis and because the cause of longitudinal melanonychia is usually not apparent. Accordingly, biopsy is often necessary to establish the cause. This review attempts to expedite management by providing suggestions for the examination of patients with this disorder. The causes of longitudinal melanonychia are enumerated and clues to arrive at the various causes are discussed. Similarities between longitudinal melanonychia and subungual melanoma are discussed in an effort to clarify their differences and similarities; clues to the diagnosis of subungual melanoma are also discussed. Various biopsy techniques applicable to longitudinal melanonychia are considered and the indications for different surgical approaches are emphasized. The importance of the pathologist in interpreting nail biopsy specimens is emphasized.

Biopsy↗
PubMed1987

Nail biopsy vignettes.

Several important aspects of nail biopsies are reviewed: techniques for reliably demonstrating dermatophytes within the nail unit; the use and advantages of double action nail clippers; biopsy by the double punch method; risk/benefit considerations in preoperative patient discussions; malignancies masquerading as nail dystrophies; selected aspects of anesthesia and hemostasis; and the importance of communication between the dermatologist and pathologist in assuring accurate nail biopsy interpretation.

Biopsy↗
PubMed1986

Hypopigmented mycosis fungoides. Speculations about the mechanism of hypopigmentation.

Hypopigmented, nonatrophic macules are an unusual manifestation of lesions of early mycosis fungoides. Presented herein is a patient with such lesions and an unusual mask-like hypopigmentation of the face. We review both the clinical and microscopic findings in this patient and in previously reported patients with hypopigmented lesions of mycosis fungoides. Finally, speculation is made as to the mechanisms of the hypopigmentation.

Adult↗
PubMed1985

Conjunctivitis.

Explore the source record for details and available documents.

Conjunctivitis↗
PubMed1985

Onycholysis of the fingernails: evaluation and management.

Onycholysis (ONY) of the fingernails is a common disorder that is diagnosed with ease but often managed with great difficulty. The full spectrum of causes is broad and not always readily apparent. In this review, an approach to the evaluation and management of ONY is offered.

Anti-Bacterial Agents↗
PubMed1985

Brittle fingernails.

In this review an attempt has been made to clarify the etiology, pathogenesis, and therapy of brittle fingernails. Hopefully, this discussion will enable the clinician to better understand, evaluate and manage patients with this disorder.

Anemia, Hypochromic↗
PubMed1982

The role of tar in Goeckerman therapy.

Seventeen patients with psoriasis were treated with 5% crude coal tar in an absorbent ointment base (Aquaphor) to one half of the body and with the absorbent ointment base alone to the other half. They received twice-daily erythemogenic doses of ultraviolet irradiation (UVR). Both modalities, crude coal tar and absorbent ointment base alone, combined with UVR were equally effective in improving psoriatic plaques. On the basis of this and previous studies, we question the therapeutic role of tar in the Goeckerman regimen.

Adult↗
PubMed1981

Rickettsialpox: report of an outbreak and a contemporary review.

Rickettsialpox is a mild illness characterized by the appearance of a primary eschar at the site of a mite bite followed by fever, headache, and a papulovesicular rash. It can be confused with a variety of illnesses including several other rickettsial diseases and chickenpox. R. akari, the etiologic agent, is a rickettsia belonging to the spotted fever group (SFG) of rickettsial illnesses. In spite of significant serologic cross-reactivity with other SFG agents, there is no convincing evidence of cross-immunity to these agents after recovery from rickettsialpox. Tetracyclinie is the drug of choice in the treatment of this disease.

Adult↗
PubMed1976

Intravenous desensitization to mechlorethamine in patients with psoriasis.

Eight patients with psoriasis who had developed contact allergy to mechlorethamine hydrochloride (nitrogen mustard) were subjected to a regimen of intravenous infusion of small amounts of the drug in an attempt to produce desensitization. Although three of eight developed negative patch tests and were presumed to be desensitized, only one patient was able to use the drug therapeutically, and then only for a period of eight months, after which allergy recurred. The other two patients whose allergic contact dermatitis was abolished by the infusions were unable to use mechlorethamine therapeutically because of pruritus. Seven patients experienced some adverse reaction to the infusion. Intravenous desensitization of psoriatic patients who are allergic to mechlorethamine was not successful enough as a useful clinical procedure to allow them to once again use the drug therapeutically.

Administration, Topical↗
PubMed1975

Mechlorethamine in psoriasis. Further attempts to induce immunological tolerance.

Further attempts to induce immunological tolerance in 29 psoriatic patients treated topically with mechlorethamine hydrochloride have not been successful using the intravenous route. The rate of sensitization achieved (65%) is not substantially different from the rate for those patients who had no attempt to induce tolerance (55.5%).

Adult↗