Natural history of disease and placebo effect.
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Disease↗
Biomedical subjects
P Kelkar
Publications and source records attributed to P Kelkar.
Neural control of the heart. Central and peripheral.
The central nervous system through its modulation of autonomic activity plays an important role in maintaining homeostasis in the cardiovascular system and in integrating cardiovascular responses with behaviors. Thus, central and autonomic disturbances can lead to profound alterations in cardiac function manifested by cardiac arrhythmias and signs of myocardial injury. These disturbances can further compromise patients with primary central lesions. Rapid recognition and appropriate treatment of the cardiac complications as well as the underlying condition are critical for effective management of many such patients.
Arrhythmias, Cardiac↗
Effect of Blalock Taussig shunt on clinical parameters, left ventricular function and pulmonary arteries.
Twenty children (mean age 3.25 years) with congenital cyanotic heart disease undergoing modified left Blalock-Taussig (BT) shunt were studied. The mean follow-up period was 9.5 months (range 6 months to 1 year). The shunt was performed for cyanotic spells in 15 (75%) and hypoplastic pulmonary arteries in 5 (25%) patients. There were no immediate or late complications. None had cyanotic spell after the shunt. The mean arterial oxygen saturation improved from 66.47 +/- 11.9 to 76.97 +/- 8.16% (p = 0.0003) and mean hematocrit decreased from 51.55 +/- 9.5 to 46.5 +/- 9.7 (p = 0.002) after the shunt. The left atrial systolic volume and left ventricular diastolic volume also increased significantly following the shunt (from 15.82 +/- 6.37 to 20.83 +/- 8.91 ml p = 0.006 and from 36.13 +/- 16.08 to 41.08 +/- 20.07 ml (p = 0.01) respectively. There was significant growth of main, right and left pulmonary arteries and pulmonary valve annulus after the procedure.
Blood Flow Velocity↗