Biomedical subjects
Publications and source records attributed to P Kerscher.
Anorexia is a common psychiatric condition of childhood and adolescence in which, apart from the striking psychopathology, somatic complications are frequently seen. The secondary somatic findings, however, are sometimes overlooked. This case report describes a 17-year-old girl in whom, during an episode of bulimia dilatation of the stomach occurred, which presented clinically as perforation.
beta-lipotropin stimulates lipolysis in the rabbit in a dose dependent manner. Besides glycerol and free fatty acid release a significant increase of betahydroxybutyrate as well as of acetoacetate was observed while pyruvate decreased significantly. Glucose and lactate levels remained unchanged. Our data suggest that lipolysis induced by beta-LPH and its effect on ketogenesis is more important than the actual plasma concentration of insulin.
beta-endorphin stimulates lipolysis in vitro in isolated fat cells of the rabbit. To exclude effects of collagenases and local proteases we investigated the effect of beta-endorphin on glycerol, free fatty acids and glucose plasma levels in the rabbit with and without naloxone. beta-endorphin increased free fatty acids and glycerol while glucose remained unaffected. The increase of glycerol and free fatty acids could be blocked by naloxone, suggesting the involvement of different receptors.
Within 11 years 279 operations for acute bleeding from gastroduodenal ulcers were performed at the surgical University Clinic in Würzburg. Of the 279 patients, 140 had to be operated on immediately because of acute severe bleeding. Of the 158 bleeding duodenal ulcers, 104 had a selective proximal vagotomy (SPV), 29 had gastric resection, and in 25 the ulcer was simply closed. The overall mortality after SPV was 8.6%, 62% after gastric resection, and 40% after simple suture ligation. Recurrent bleeding occurred in 8.7% after SPV, 10.3% after gastric resection, and in 24% after suture ligation. Of the 89 bleeding gastric ulcers, 25 had a selective proximal vagotomy, 30 a gastric resection, and 34 excision of the ulcer. The overall mortality after SPV was 16%; after gastric resection it was 23.3% and 41.2% after ulcer excision. Recurrent bleeding was observed in 8% after SPV, in 10% after gastric resection and in 11.7% after ulcer excision.
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A comparison of three different suture techniques on the large bowel of the same experimental animal demonstrated that careful suture alone is adequate to produce a sufficient anastomosis. The advantages of this suture technique are to provide strength to the intestinal anastomosis, less scar tissue, and fewer peritoneal adhesions. The experimental results suggest that suturing of the submucosa can be used on other intestinal areas, too.