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Biomedical subjects

P Kh Nazirov

Publications and source records attributed to P Kh Nazirov.

9 recordsLinked to original sources
PubMed2004

[New approaches to formation of registration group of individuals followed up by antituberculosis institutions in Uzbekistan].

The paper presents the results of a three-year (2000-2002) follow-up of the movement of dispensary contingents registered in tuberculosis facilities in order to develop new dispensary groups. The dispensary groups of patients with active forms of tuberculosis have been ascertained to accumulate a great number of patients with its inactive forms due to the untimely of their transfer to the inactive groups in terms of effective treatment and the clinical forms of tuberculosis. New dispensary grouping will more definitely regulate the transfer of patients from active to inactive groups and strike from the list of dispensary patients. The proposed new grouping excludes registration Groups 0, II, and VII. If required, the persons struck from Groups III and VB and those followed up as Groups 0 and VII patients will be transferred to adult and pediatric polyclinics and followed up in recurrent tuberculosis risk groups.

Adolescent↗
PubMed2004

[Results of surgical treatment of complicated forms of tuberculous spondylitis].

The results of surgical treatment of tuberculous spondylitis were studied in 93 patients, including 45 patients living in poor environmental areas (Group 1) and 48 residing in good environmental areas (Group 2). The patients underwent clinical, laboratory, X-ray tomographic, ultrasound, functional, and electric neuromyographic studies. Analysis of the results of the study established that despite their short histories of the disease, in Group 1 patients, there was affliction of more than 3 vertebrae in 58.1% of the cases, spinal cord dysfunction in 42.2%, decreased bone tissue sound conductivity in 8-12% as compared with Group 2 patients. A comparative deceleration of graft joining was found in 52.4% of the patients. Complete recovery of spinal cord function occurred in 87.3% of the cases. A complex conservative and pathogenetic and pathogenetic (osteogenon and shilajat-asil) and early surgical treatment of tuberculous spondylitis was ascertained to enhance the efficiency of therapy and to reduce the length of hospital stay to 1 month.

Adolescent↗
PubMed2002

[Spinal and pulmonary tuberculosis].

The paper presents the results of a study of the clinical course of tuberculous spondylitis of combined pulmonary tuberculosis in 86 patients admitted from different areas of the Republic of Uzbekistan. Patients with tuberculosis of the spine and lung have been shown to have a more unfavourable course of a specific process in the bony tissue and lung. The tuberculous process is accompanied by severe intoxication, pain syndromes. The severity of the process is aggravated if there are extensive suppurative processes around an osseous focus. These patients have varying severe cerebrospinal disorders. Moreover, patients with combined forms of the process more frequently exhibit concomitant nonspecific visceral diseases.

Adult↗
PubMed2001

[Ultrasonic diagnosis of tuberculosis of major joints in children and adolescents].

Results of ultrasonic echotomography (UET) are available for 42 patients with affection of major joints. Provocation with tuberculin (20 TU) was made. UET data before and 3-5 days after the provocative test were compared. Reactive inflammation at the site of tuberculosis-affected joint caused by the provocation test was reflected by UET. This method detected early tuberculous lesion of the joints in 34 examinees.

Adolescent↗
PubMed1993

[Immune status in patients with bone and joint tuberculosis and effect of HLA genotype].

The study included 41 patients (Uzbeks by nationality) with tuberculosis of the bones and joints. Of them 19 had localized tuberculosis and 22 disseminated process. The condition of T lymphocytes, B-lymphocytes and specific immunity were investigated by standard immunological methods. Typing by antigens HLA-DR was made with the help of standard microlymphocytotoxic test. It was established that patients with tuberculosis of the bones and joints have worse qualitative and quantitative characteristics of T lymphocytes, reduced number of B-lymphocytes, high specific response of lymphocytes to tuberculin compared to healthy subjects. Such patients have low B-cell level when they are free of antigen HLA-DR4. Carriers of HLA-DR2 antigen exhibit inhibited specific cellular immunity compared to those without this antigen.

B-Lymphocytes↗
PubMed1991

[HLA antigens in patients with osteoarticular tuberculosis with different disease course].

Examination included 93 Uzbek patients with osteoarticular tuberculosis: 37 had localized and 56 disseminated tuberculosis process. All the patients were typified according to the HLA antigen locuses-A, B, C and DR by the standardized microlymphocytotoxic test. As a control, 135 healthy Uzbeks were typified by antigens of the same HLA locuses (105 subjects were typified by antigens of the HLA-DR locus). The patients with osteoarticular tuberculosis were found to have genetically controlled susceptibility to tuberculosis infection. The frequency of HLA, B7, B27 and DR2 antigens occurrence in tuberculosis patients is increased as compared to that in healthy subjects. In patients with a disseminated tuberculosis process, the frequency of HLA-Cw4 and HLA-DR4 antigens was increased to 33.9% and 44.6%, respectively, as compared to that in patients with a localized process (5.4% and 21.6%, respectively).

Disease Susceptibility↗
PubMed1991

[HLA antigens in patients with osteoarticular tuberculosis and chronic hematogenic osteomyelitis].

There have been examined 93 patients with the tuberculosis of bones and joints, 28 patients with chronic hematogenic osteomyelitis. All patients have been typed in accordance with the antigens of loci HLA-A, B, C and DR by means of standard microlymphocytotoxic test. 135 healthy donors have been typed according to the same loci++ HLA as controls (105 persons have been typed according to antigens of locus HLA-DR). All examined persons have been Uzbeks. There have been stated that in the patients with the tuberculosis of bones and joints, as compared with osteomyelitis, is observed the increase of frequency of antigens HLA-B27 and HLA-DR2, while in case of bone osteomyelitis is noted association with antigens HLA-A9, B7 and B18.

Chronic Disease↗