From melanotic to amelanotic lentigo maligna: an aggressive variant presenting as an inflammatory lesion.
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Aged↗
Biomedical subjects
P Kiene
Publications and source records attributed to P Kiene.
[Unusual circinary variant of generalized granuloma anulare].
We report on a 56-year-old male patient with annular, erythematous and slightly elevated lesions measuring up to 12 cm in diameter on the trunk. Histologically a diffuse mononuclear infiltrate with histiocytic giant cells was present. His condition is a rare variant of generalized granuloma annulare in association with diabetes mellitus.
Biopsy↗
[Dermatitis papulosa juvenilis].
Juvenile papular dermatosis is characterized by hypopigmented lichenoid flat papules with predilection for the dorsa of the hands, the elbows and the knees. The disease affects children in the summer months. Changes observed in biopsy specimens show hyperkeratosis, a moderate degree of acanthosis and a lymphocytic perivascular infiltrate in the upper dermis. The pathogenetic influence of such rough materials as sand and wool and of photosensitivity in atopic patients is suggested. We report on a 9-year-old boy who developed lesions of juvenile papular dermatitis (especially severe on the face and the back of the knee) and extreme pruritus for the first time in summer 1994.
Biopsy↗
[Rheumatoid neutrophilic dermatitis--a rare dermatosis in patients with active rheumatoid arthritis].
Rheumatoid neutrophilic dermatitis is a rare dermatologic disorder seen in patients with active rheumatoid arthritis. Clinically firm erythematous 3-5 mm papules are found mainly on the arms, the hips and the proximal thighs. The lesions may be pruritic leading to excoriations and crusts. Histology reveals a dense dermal infiltrate with neutrophilic granulocytes, while leukocytoclasia may be seen, vasculitits is not observed. This overview of rheumatoid neutrophilic dermatitis may help remind the practitioner to include this uncommon disorder in the differential diagnosis of rheumatoid arthritis-related dermatoses.
Arthritis, Rheumatoid↗
Nodular balloon cell component in a cutaneous melanoma of the superficial spreading type.
The rare histopathologic feature of a nodular balloon cell component in a malignant melanoma of the superficial spreading type in a 46-year-old male patient is presented. Immunohistochemical analyses proved the tumor cells to express the melanocytic markers S100 protein, NK1/C3 and HMB 45 antigens in an intense and distinct pattern. The controversial theories of the pathogenesis of balloon cell changes in melanocytic neoplasms are discussed.
Biomarkers↗
Eruptive vellus hair cysts and steatocystoma multiplex. variants of one entity?
Eruptive vellus hair cysts and steatocystoma multiplex are two clinically similar conditions which show multiple papules and nodules, mainly located over the anterior chest wall. Most cases can be differentiated on histological examination, but in some patients overlapping histological features have been described. We present a patient who showed features of both entities and interpret this as suggesting that eruptive vellus hair cysts and steatocystoma multiplex are variants of one disorder which originates in the pilosebaceous duct.
Adult↗
["Blue" variant of naevus spilus].
We report on a 29-year-old female patient with an unusual pigmented lesion of the face. Clinically the lesion looked like a pigment patch of the naevus spilus type, while histological examination revealed the presence of dermal melanocytosis and multiple common blue naevi with a discrete lentiginous component in addition. The melanocytic nature of the infiltrate was ascertained by immunohistochemistry analysis using S 100 protein and HMB 45 antibodies. We interpret this lesion as agminated blue naevi in association with lentigo simplex, an unusual variant of speckled lentiginous naevus.
Adult↗
[Parakertosis variegata after pityriasis lichenoides et varioliformis acuta].
We report on a 34-year-old male patient who developed generalized parakeratosis variegata lesions 4 years after suffering from pityriasis lichenoides et varioliformis acuta. For further investigation of a possible interrelationship between these two diseases of the parapsoriasis group and their relationship to the T-cell type of cutaneous non-Hodgkin-lymphoma, histological, immunohistological and molecular-biological techniques were applied. We were able to demonstrate typical morphological features common to both diseases, and a polyclonal T-cell infiltrate in both. It is concluded that pityriasis lichenoides et varioliformis acuta and parakeratosis variegata are separate entities without monoclonal rearrangement or signs of malignancy.
Adult↗
Pigmented pedunculated malignant melanoma. A rare variant of nodular melanoma.
We report a 44-year-old man who presented with a rapidly growing, deeply pigmented, pedunculated tumour. The lesion was diagnosed as a pedunculated malignant melanoma, a rare variant of nodular malignant melanoma. The clinical presentation of this tumour and its histological features are discussed.
Adult↗
No evidence of human papillomavirus infection in balanitis circumscripta plasmacellularis Zoon.
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Adult↗
Guttate and plaque psoriasis.
Guttate and plaque psoriasis are regarded as variants of one disease but present with distinct clinical and histologic appearances. This article focuses special attention on different pathways in the development and clinical course of each, with emphasis on immunologic correlations regarding HLA system linkage and therefore genotypical expression. The differences in the variants are also important in treatment regimens.
Genetic Linkage↗
A simple and rapid technique to process formalin-fixed, paraffin-embedded tissues for the detection of viruses by the polymerase chain reaction.
The use of chelating resin in a simple, rapid and efficient pre-treatment protocol to process formalin-fixed, paraffin-embedded specimens for the polymerase chain reaction (PCR) is described and compared to other pre-treatment techniques. With this modified PCR protocol, a variety of human autopsy and biopsy specimens were investigated for presence of DNA of human papilomaviruses, cytomegalovirus or Epstein-Barr virus. These viruses were detected in a productive or non-/low-productive state. Amplimers generated ranged from 88 to 450 base pairs length. Under the specified technical conditions, a considerable range of DNA molecules can be amplified from paraffin-embedded material, some older than 10 years.
Acquired Immunodeficiency Syndrome↗
Human papillomavirus infection in vulvar lesions of lichen sclerosus et atrophicus.
Human papillomaviruses (HPV) types 6, 11, 16 and 18 infections were investigated in 18 vulvar lesions of lichen sclerosus et atrophicus (LSA) using in situ DNA hybridization and polymerase chain reaction (PCR) on formalin-fixed paraffin-embedded specimens. Four out of 18 specimens were found to be infected with HPV type 16 using the PCR technique. Interestingly, three of these four patients were in a premenopausal state. This difference proved to be the only distinguishing feature in a comparison of HPV type 16-infected patients with non-infected patients. In situ hybridization revealed no positive result in any case and PCR demonstrated no HPV-DNA type 6, 11 or 18. Patients with HPV type 16-infected lesions may be regarded as at risk of developing vulvar cancer. Therefore, long-term follow-up of this subgroup is particularly important.
Adult↗