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Biomedical subjects

P Kitching

Publications and source records attributed to P Kitching.

44 records · Page 3Linked to original sources
PubMed1987

Precocious and premature puberty associated with treatment of acute lymphoblastic leukaemia.

Early puberty in 28 children (23 girls, five boys) treated for acute lymphoblastic leukaemia (ALL) at a mean age of 4.0 years (range 1.4-7.8) is described. All but one had received prophylactic cranial irradiation (1800-2400 cGy) and three children had received additional cranial or craniospinal irradiation as treatment for relapse of their leukaemia. Mean age for the onset of puberty was 8.8 (SD 0.8) years in the girls and 9.3 (0.8) years in the boys; this is greater than two standard deviations from the mean for normal girls and boys. Five children (three girls, two boys) had precocious puberty. The onset of puberty occurred at greater than two standard deviations from the mean for normal girls and boys in 14(13%) girls and 4(3%) boys treated at less than eight years of age between 1970 and 1985. In a group of 55 girls treated for ALL who had survived in first remission for six years or more from diagnosis, there was a relation between young age at onset of treatment and early menarche. We suggest that premature activation of the hypothalamic-pituitary-gonadal axis occurs as a consequence of hypothalamic dysfunction due to cranial irradiation. Precocious and premature puberty in children treated for ALL may be an important factor in contributing to short stature.

Age Factors↗
PubMed1983

Progress towards sheep and goat pox vaccines.

Sheep pox and goat pox are diseases of sheep and goats caused by pox virus. The variety and range of clinical signs produced by a single strains of virus in different breeds and age groups of animal tends to overlap those produced by different viruses within the same group or even different groups of pox viruses. Thus, contagious pustular dermatitis, easy to diagnose in countries considered free of sheep and goat pox, is probably frequently diagnosed as sheep or goat pox where the diseases co-exist. In the past, vaccinia infection of sheep and goats could also have been misdiagnosed.

Animals↗