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Biomedical subjects

P Kjaersgaard-Andersen

Publications and source records attributed to P Kjaersgaard-Andersen.

At least 55 records · Page 3Linked to original sources
PubMed1988

Indomethacin inhibits the recurrence of excised ectopic ossification after hip arthroplasty. A 3-4 year follow-up of 8 cases.

Eight patients were treated with indomethacin and excision of paraarticular ossification after hip arthroplasty. In 1986 we reported that after 3 months substantial ossification had recurred in only 2 patients. We now report that ossification had not progressed further at follow-up 3-4 years later. All 8 patients were painfree and the majority had good hip motion. We conclude that indomethacin permanently prevents recurrence after excision of paraarticular ossification.

Aged↗
PubMed1988

The use of indomethacin to prevent the formation of heterotopic bone after total hip replacement. A randomized, double-blind clinical trial.

We studied the effect of indomethacin on the prevention of formation of heterotopic bone after total hip replacement. In a randomized, double-blind clinical trial involving 201 patients, 102 patients received twenty-five milligrams of indomethacin three times daily for the first six postoperative weeks, and the other ninety-nine patients received a placebo. One year after the operation, eighty-nine of those who had received indomethacin had no sign of heterotopic ossification, and the remaining thirteen had a grade-I lesion. In the group that had received a placebo, twenty-seven had no heterotopic ossification; twenty-four, a grade-I lesion; thirty, a grade-II lesion; and eighteen, a grade-III lesion. Significantly fewer patients who had received indomethacin had formation of heterotopic bone compared with those who had been given a placebo (chi-square test, p less than 0.0005). Only patients who had grade-III formation of heterotopic bone had a significant reduction in movement of the hip.

Adult↗
PubMed1988

Serum alkaline phosphatase as an indicator of heterotopic bone formation following total hip arthroplasty.

Serum alkaline phosphatase (SAP) was analyzed in 193 patients treated with total hip arthroplasty (THA) and correlated with the degree of heterotopic bone formation (HBF) one year after surgery. The influence of indomethacin on changes in SAP related to the development of heterotopic bone was studied. Ninety-eight patients received 25 mg of indomethacin three times daily for the first six postoperative weeks; the remaining 95 patients received a placebo treatment. No further anti-inflammatory drugs were allowed during the six weeks. SAP was measured preoperatively and six weeks and 12 weeks after surgery. No patients at risk for developing heterotopic bone after THA could be identified from the preoperative level of SAP. The level of SAP six weeks after THA gradually increased with the amount of HBF. A rise in SAP above 250 IU/liter 12 weeks after surgery was associated with the development of severe heterotopic bone in 13 of 17 patients. Indomethacin inhibited the development of heterotopic bone associated with a rise in SAP following THA. Future studies on HBF and SAP following THA should include information on patient use of anti-inflammatory drugs in the early postoperative period.

Adult↗
PubMed1988

Ruptured tibialis posterior tendon in a closed ankle fracture.

Interposition of a ruptured tibialis posterior tendon between the medial malleolar fracture fragments in a closed pronation-eversion ankle fracture occurred in a 21-year-old woman. The tendon rupture was not diagnosed before surgery but was recognized at the time of open reduction. the tendon was repaired and the fracture internally fixed. Twelve months after the operation, the patient had a nearly full range of pain-free ankle movements and a normal longitudinal arch.

Adult↗
PubMed1987

Knee arthroplasty in rheumatoid arthritis. Four- to six-year follow-up study.

A consecutive series of total condylar knee arthroplasties in patients with rheumatoid or related arthritis, with a 4-6-year follow-up period, was studied. Eighty-seven percent had an excellent or good overall result (score of 70 or more on the HSS knee rating scale). The median total score increased from 45 points before operation to 83 after operation. Sixteen complications, mostly minor, occurred in 14 patients. There were no early infections. Two prostheses were removed for deep infection, after 3 and 5 years. One patient had patellectomy for avascular necrosis. The crude prosthesis survival rate was 97%. Tibial radiolucencies were noted in 76% of cases; in 29% they were significant (2 mm or more in one or more of three zones). Two tibial components (2%) were believed to be mechanically loose, but no revisions for mechanical loosening were done. The presence of radiolucencies did not signify an inferior clinical result.

Adult↗
PubMed1987

Lateral talocalcaneal instability following section of the calcaneofibular ligament: a kinesiologic study.

In the evaluation of the role of the calcaneofibular ligament in stabilizing the talocalcaneal joint, an experimental set-up was prepared. In 10 osteoligamentous specimens, the talocalcaneal motion was measured under a constant well defined moment by using a specially constructed apparatus. By using a moment of 1.5 Nm, increment in adduction in the talocalcaneal joint after section of the calcaneofibular ligament was found between 3.1 degrees and 4.6 degrees, still increasing with dorsiflexion. This increment, shown to constitute 61 to 77% of the total increment in adduction in the hindfoot after section of the calcaneofibular ligament, was found to increase gradually with dorsiflexion. The study has shown the calcaneofibular ligament as an important structure in stabilizing the talocalcaneal joint. Increment in adduction in the hindfoot after section of the calcaneofibular ligament was shown primarily to take place in the talocalcaneal joint.

Cadaver↗
PubMed1987

Effect of the calcaneofibular ligament on hindfoot rotation in amputation specimens.

A kinesiologic study of the range of rotation in the hindfoot after cutting of the calcaneofibular ligament was performed in amputation specimens. Cutting of the calcaneofibular ligament results in a significant increment in the external rotation of the tibial-talocalcaneal joint complex and the talocalcaneal joint, maximum 5.4 degrees and 2.9 degrees, respectively. The total range of rotation in the tibial-talocalcaneal joint complex and the talocalcaneal joint increased 32 and 20 per cent, respectively. The calcaneofibular ligament is an important structure in the rotatory stabilization of the hindfoot.

Amputation, Surgical↗
PubMed1986

Indomethacin for prevention of ectopic ossification after hip arthroplasty.

Twelve patients at risk of developing postoperative para-articular ossifications were treated with indomethacin. Ossification after previous total hip arthroplasty was excised in eight patients. Four patients had ossification in the opposite hip after previous arthroplasty. Five patients in whom ectopic ossification was excised developed recurrences of lesser degree than the primary ossifications. One patient with the condition in the opposite hip developed ossification. No patients complained of stiffness in the hip and all had markedly increased hip motion. Indomethacin seems to be valuable as prophylaxis in patients at risk of developing ectopic ossification and as a supplement to secondary excision.

Aged↗
PubMedDate not supplied

The stabilizing effect of the ligamentous structures in the sinus and canalis tarsi on movements in the hindfoot. An experimental study.

Three-plane kinesiology of hindfoot instability was studied after lesions to the ligamentous structures in the sinus and canalis tarsi in 20 amputation specimens. Neither a lesion of the cervical ligament nor of the interosseous talocalcaneal ligament resulted in an increase in the total range of movements above 2.6 degrees in any of the three planes. However, the percentage increase in the total range of movements after cutting of the ligaments was generally largest in the talocalcaneal joint compared to the increase in the total hindfoot joint complex. The largest percentage increase (43%) in the talocalcaneal joint occurred at dorsiflexion after cutting the interosseous talocalcaneal ligament. The demonstrated minor instability after experimental lesions of the ligamentous structures in the sinus and canalis tarsi may have a clinical identity in the sinus tarsi syndrome. Patients with that syndrome rarely present an objective hindfoot instability, although a major complaint is a feeling of hindfoot instability.

Ankle Joint↗