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Biomedical subjects

P Knöll

Publications and source records attributed to P Knöll.

At least 19 recordsLinked to original sources
PubMed2005

[Histomorphometric evaluation of bone ingrowth of porous titanium by a computer-assisted analyzing system].

The objective of this study was to evaluate the bone ingrowth of a new vacuum plasma sprayed titanium surface (vps-ti) in comparison to cs-titanium implants in a göttinger minipig model. Fifteen göttinger minipigs each received the two implants, vacuum plasma sprayed titanium with a porosity of 50% and a pore size of 200 microm (vps-ti) and an implant with a similar porosity but a different pore size 500 microm (cs-ti), at the proximal femur metaphysis by press-fit technique. The pigs were euthanized at three different postsurgical periods: 4, 8 and 12 weeks. Each femur was harvested and qualitative (macroscopic and microscopic) and quantitative (histomorphometric) histological analysis was done on histological slides. The results indicated that there was a difference in bone ingrowth between the two implants, whereas the bone ingrowth of vps-ti was superior to cs-ti after 4 and 8 weeks healing time. 12 weeks post implantationem no statistiscal difference was evident. The pore size of 200 microm seemed superior to a pore size of 500 microm. Whether or not these effects lead to a better mechanical stability remains unanswered.

Animals↗
PubMed1990

[Transitory bacteremia in bronchologic-biopsy procedures].

In 105 patients, the incidence of transitory bacteraemia seen following bronchological-bioptic interventions was investigated. In three patients (2.9%), the identical pathogens were detected both in the bronchial secretion and in venous blood culture following bronchoscopy.

Bacteria↗
PubMed1988

[Complications in endoscopic and endoscopic biopsy studies--analysis of a 1-year patient sample].

We report on a prospective study of complications in 2,133 bronchoscopies, 61 transthoracic lung biopsies, 32 mediastinoscopies and 6 thoracoscopies, performed between 1985 and 1986. There were no deaths or life threatening complications. The total rate of essential complications, e.g. pneumothorax, haemorrhage, laryngospasm, and bronchospasm of all patients with bronchoscopies was 10.5%. Excluding small endobronchial haemorrhages, without influence on the patients state or endoscopic procedures the final rate of complications was 1.9%.

Biopsy↗
PubMed1987

[Experiences with bronchoalveolar lavage in disseminated and other lung diseases].

In 860 patients 980 bronchoalveolar lavages were performed. The repeated BAL allows conclusions of the effect of treatment and the prognosis of the disease. BAL is together with other clinical findings an important new method in pulmology. Its value in diagnosis of interstitial pulmonary diseases and other pulmonary diseases is described with special view to occupational expositions.

Alveolitis, Extrinsic Allergic↗
PubMed1986

[Bacteriological findings in selected inflammatory bronchopulmonary diseases].

Actual bacterial flora was bronchologically examined in 561 patients with inflammatory bronchopulmonary diseases, 291 out of them with acute pictures. Facultative pathogenic organisms were found in 70 per cent of bronchiectases, in 24.4 per cent of pneumonia and in 17 per cent of acute bronchitis. In the first place of infections were Haemophilus influenzae and gram-negative bacteria; in contrast to that pneumococci and staphylococci were less frequent. Sensitivity tests showed that especially in the case of gram-negative organisms and staphylococci a well-directed antibiotic treatment should be carried out.

Anti-Bacterial Agents↗
PubMed1986

[Differential diagnosis of paragonimiasis in relation to tuberculosis of the lung by transthoracic needle biopsy].

In a citizen of the People's Democratic Republic of Laos who has entered the German Democratic Republic for professional training a lung involvement in the shape of a circular focus was established after pleurisy. Hospitalization followed from suspected tuberculosis. Worm eggs of a lung fluke were parasitologically detected in a transthoracic fine needle biopsy. After administering Biltricide the patient undergoes follow-up treatment as an outpatient. No symptoms have ever occurred since. In a differential diagnosis paragonimiasis in the event of unclear pulmonary infiltrates in citizens from South-East Asia should be taken into consideration in the face of pulmonary tuberculosis, and should be cleared up in an etiological diagnosis, if necessary.

Adolescent↗
PubMed1986

[Value of bronchoalveolar lavage for the diagnosis of adenocarcinoma of the lung].

The differentiation of interstitial lung diseases and disseminated lung tumors only by radiological methods is impossible. Cytological or histological examinations of specimens taken by bronchological or surgical examinations are able to confirm the diagnosis. In two cases of a disseminated process in which other bronchological diagnostic methods failed we found cells of an adenocarcinoma by BAL. We recommend this method for differential diagnostic between interstitial lung diseases and disseminated intraalveolar carcinoma, especially bronchiolo-alveolar carcinoma.

Adenocarcinoma↗
PubMed1980

[Chemotherapy of malignant solid tumors].

In the chemotherapy of malignant solid tumours, also in form of the adjuvant chemotherapy, the results to be yielded are less favourable than in the diseases of the hemopoietic system. By a consequently performed poly-chemotherapy it is, nevertheless, possible to achieve remissions. By polychemotherapy we achieved in 13 metastatasized carcinomas of the mamma 4 partial and one complete remission, in 15 inoperable lung tumours we achieved four times a standstill of the growth and a complete remission over two years, whereas the tumours of the gastro-intestinal tract could be influenced less clearly. Treatments with only one medicament in each case were without any effect in solid epidermic tumours. The therapy is to be used effectfully only then, when indication, dosage and control of the patients are performed critically and exactly.

Bleomycin↗
PubMed1980

[Comparative studies of bronchial flora by means of a conventional and a new technic of taking specimens (author's transl)].

A modification of a method described by LEES and MCNAUGHT for taking of bronchial specimens for bacteriological examination is reported and compared with the usual taking of specimens in a group of 275 patients. Working with the new method the contamination decreased from 55% to 20% of the examined patients. These contaminations in the new method are easy to distinguish from the real settlement of germs to separate. In patients with pyogenic bronchitis a higher percentage of positive bacterial cultures is to be found. The use of this method in hospitals is recommended.

Bronchi↗
PubMed1978

[Comparison of three serological methods for determination of antistreptokinase following fibrinolytic therapy (author's transl)].

By means of three different reactions, precipitation, passive haemagglutination and the determination of antifibrinolytic antibodies the formation of streptokinase antibody after streptokinase treatment was investigated. The earliest antistreptokinase we found with the passive haemagglutination reaction at day 4 on the beginning of streptokinase therapy. Precipitating and antifibrinolytic antibodies were found at day 7. One patient did not develope precipitating, an other formed no haemagglutinating streptokinase antibodies, the reason is discussed.

Antibodies↗