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Biomedical subjects

P Kohn

Publications and source records attributed to P Kohn.

At least 19 recordsLinked to original sources
PubMed1992

An infectious disease day care unit--the first year.

Details are given of what is believed to be the first Day Care Unit in the U.K. for the diagnosis and treatment of infection and infectious diseases. The reaction of referring doctors and their patients has been favourable, cross-infection in the home has not been a problem and some potentially life-threatening infections have been diagnosed earlier than might otherwise have been the case. Capital and running costs were relatively small and the use of inpatient beds for infectious diseases became more efficient.

Costs and Cost Analysis↗
PubMed1977

[Effect of furosemide on venous capacity in anuric or binephrectomized patients].

Several reports about an extrarenal effect of Furosemide, consisting in venodilatation and venous pooling have been published during the last years. Some authors however deny any extrarenal effect. Changes in venous capacity of the leg were measured before and after Furosemide administration in anuric and binephrectomized patients, using the technique of occlusive rheography. According to the augmented venous pooling, all patients showed a significant decrease of venous capacity after Furosemide. This effect is certainly extrarenal.

Adolescent↗
PubMed1976

[Prophylactic effect of isosorbide dinitrate on postoperative cardiac complications (author's transl)].

Isosorbide dinitrate (ISD) was administered before, during and after 178 operations performed on 127 patients with arterial occlusive disease. Its influence on postoperative myocardial infarction, heart failure and mortality was tested by comparison with 188 operations performed on 140 patients with hypertension and/or old myocardial infarction receiving no ISD prophylaxis. Risk of cardiac complications was similar in both groups. Mortality in the ISD-treated group was significantly lowered as compared with the control group and was about half of the overall mortality in patients with arterial occlusive disease operated on at our hospital over the past 10 years. This difference depended partly on the influence of ISD on cardiac complications. Post-operative myocardial infarction during ISD prophylaxis occurred in 0.6% of cases as compared with 3.7% in the control group (p less than 0.05), whilst the respective values for postoperative heart failure were 5.7% and 18.2% (p less than 0.001). Both complications are related to absolute or relative hypoxia during the post-operative stress period. ISD is effective by lowering cardiac preload and afterload and thereby diminishing myocardial oxygen demand. ISD is the drug of choice for surgical patients since it provides a steady and long-lasting effect after sublingual absorption. ISD prophylaxis during the perioperative period is indicated in cases with coronary artery disease and with increased cardiac preload or afterload.

Arterial Occlusive Diseases↗
PubMed1975

[Risk factors in postoperative myocardial infarction].

Myocardial infarction after major surgery occurred 25 times in 214 patients who had previously sustained infarcts. Analysis of data obtained before, during and after 335 operations in these patients revealed the following pathogenetic factors in the infarction: (1) The patient with the highest coronary risk had arterial hypertension of at least 160/95 mmHg and advanced arteriosclerosis combined with coronary arterial, peripheral arterial, cerebrovascular, and renovascular disease. (2) Myocardial necrosis occurred when oxygen supply was reduced, as evidenced from a fall in systolic blood pressure to 70 mmHg or less during operation or anaemia (RBC smaller than or equal to 3,5 times 10-6/mul) early after operation. (3) Risk of infarction was highest during the early postoperative stress period with elevated plasma catecholamine levels and thus an increased myocardial oxygen demand.

Aged↗