Biomedical subjects
Publications and source records attributed to P Kozłowski.
We show that for a particular choice of the coupling parameters the Ashkin-Teller spin-glass neural network model with the Hebb learning rule and one condensed pattern yields the same thermodynamic properties as the four-state anisotropic Potts-glass neural network model. This equivalence is not seen at the level of the Hamiltonians.
The issue of a stabile, long lasting bone-implant interface is still very valid. One of the new models of uncemented hip prosthesis is the Bicontact prosthesis made by Aesculap. This four-part endoprosthesis offers two types of cups: threaded München type and spherical Plasmacup type. The prosthesis stem is a wedged type stem, porous in the proximal type. The aim of this paper was to evaluate the value of Bicontact prosthesis in treatment of coxarthrosis. Our material consisted of 69 patients (38 female and 31 male) with 72 operated hips. Average age of the patients was 50.8 years. The mean follow-up was 24.5 months. Clinical and radiological evaluation according to Merle d'Aubine-Postel classification with Charnley's modification yielded 88% very good and good results. In 11 hips a similar complication was noted--fracture of the femur during final hammering of the prosthesis stem into the medullary canal. This was immediately repaired by circular wire fixation without any influence on the final result. This complication was observed during the first procedures. The learning curve of surgical technique allowed us to avoid this complication during subsequent procedures. We concluded that type of hip prosthesis was is very useful in in treatment of coxarthrosis.
The use of bone cement during total hip prosthesis implantation despite it's advantages triggers of some local and general complications. The paper presents and classifies most cement related complications, with special attention to vessel complications. This paper includes an external vein injury, which occurred 5 years after a total hip replacement procedure. Chronic erosion and mechanical stress of the iliac vein by a cement hook was the cause of this complication. It has been stress that most vascular complications are a result of imperfect surgical technique.
Heterotopic ossification is the most common complication after THR. The authors present the distribution of frequency of ectopic ossification after cementless THR using Mittelmeier and Parhofer-Mönch prosthesis and it's influence on THR outcome. 151 hip joints were evaluated with a follow-up period of more than 2 years. All procedures were performed by a lateral approach. The ectopic ossification was verified according to the Brooker classification. Clinical evaluation was performed according to the d'Aubigne-Postel method in Charnley's modification. The 3rd degree ectopic ossification was found in 14 hip joint and 4th degree ectopic ossification in 2 hip joints (together 10.6%). The positive correlation between the degree of ossification (3rd and 4th) and the decrease of range of motion of the hip joint along with an increase in pain after THR was found.
The paper reports results of treatment for 5 posterior dislocations of the shoulder in 4 patients. Closed reduction was successful in 2 cases (2 days and 14 days after injury). Spontaneous reduction after removal of the Desault plaster cast 3 weeks after injury was observed in one case. Two patients with inveterate dislocation have been operated on. The defect within humeral head was filled with an allogenic bone graft in one patient and by lesser tuberosity transposition in another. Modified Constant score was used for clinical evaluation at the follow-up ranging from 5.5 months to 56 months (mean 30.4 months). Two excellent and one good result were achieved in conservatively treated cases. After surgery one result was rated poor (allograft case) and one good (lesser tuberosity transposition).
The anatomy, function and injuries of the anterior cruciate ligament were presented. The authors reviewed some technical problems concerning the intra-articular reconstruction of ACL using artificial prostheses, chemically treated allografts and xenografts or combinations of various materials. There was pointed out that none material was found to meet the criteria to be superior to autogenous graft of the middle one third of the patella tendon with its attached bony insertions.
Three different novel BRCA1 mutations, five independent cases of the same 12 bp insertion-duplication in intron-20 and two novel rare BRCA1 sequence variants were identified among 122 Polish women with positive, in most cases moderate family history of breast and/or ovarian cancer, 80 controls and 34 unselected breast cancer tissue specimens. All mutations and variants were germline. The 4153 delA frameshift mutation, the Tyr105Cys missense mutation and two cases of the alteration in intron-20 were found in the group of healthy women with positive family history. Two other cases of the intronic insertion were found in unselected controls. Their carriers had no family history of breast or ovarian cancer but other cancers occurred in their families. The 1782 Trp/STOP nonsense mutation and one case of the insertion in intron-20 were first found in tissue specimens of breast cancer patient and breast/ovarian cancer patient, respectively. Their carriers also had no family history of breast or ovarian cancer. The distribution of the insertion in intron-20 in analysed groups and results of RT-PCR experiments suggest a less prominent role for this variant considered earlier a splicing mutation. This study shows also, that more population-oriented research is needed, involving women with less profound or even no family history of breast and ovarian cancer, to better understand the role and significance of different BRCA1 variants and mutations.
The authors reviewed early clinical results in two groups of patients treated by arthroscopy-assisted (group I) and miniarthrotomy (group II) anterior cruciate ligament reconstruction. An autogenous midthird patellar tendon was used in all cases. Both groups were similar in regard to age, sex and type of injury; the same postoperative rehabilitative protocol was used. The data collected included total surgery time, blood loss, pain medication use, length of hospital stay, Lachman test results at 2, 6 and 12 weeks postoperatively; pivot shift test supplemented Lachman test at 6 months follow-up. Two statistically significant differences were found only: the blood loss was smaller in group I and surgery time was shorter in group II. Range of motion was better in group I only initially; at three months follow-up no differences were noted. The study results suggest that both open and arthroscopically assisted ACL reconstruction with midthird patellar tendon graft yield similar early clinical results.
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A 35-year-old man died after 30 months following the onset of the disease. There was a history of changes in his mental condition, including disturbances of behavior as well as the evidence of progressing dementia. The patient revealed gait disturbances and finally became bed ridden. Bizarre behavior and changes of mood with concurrent growing irritability which predominated during the course of disease, may explain the initial diagnosis of schizophrenia. Then cerebellar and spastic movement disorders leading to paraparesis and sphincters disturbances developed. Clinical symptoms of adrenal failure were not found apart from episodes of arterial pressure fall. After two years a magnetic resonance imaging (MRI) revealed an extensive diffuse demyelinative process in white matter of cerebral and cerebellar hemispheres. Activity of lysosomal enzymes was normal. A general autopsy revealed atrophy of adrenal cortex and the presence of ballooned cells with striated cytoplasm in the reticular and fasciculate zones. Neuropathological examination revealed an extensive demyelination of white matter in cerebral and cerebellar hemispheres and of the long paths of the brain stem, corresponding to changes in MRI examination. Within demyelination areas damage of axons and diffuse cellular and fibrous gliosis were found as well as perivascular lymphocytic infiltrations with the presence of strong PAS (+) and Sudan (+) macrophages. Immunocytochemical reactions with HAM-56 and RCA1 in macrophages were positive. Electron microscopy examination revealed lamellar inclusions in cytoplasm of macrophages. Similar structures were present in the lysosomes of astrocytes. Morphological examination of adrenal glands as well as morphological and ultrastructural study of the brain allowed us to diagnose the cerebral form of adrenoleukodystrophy (ALD). Topography and character of the brain changes seems to be in keeping with a rare schizophrenic-like variant of ALD with progressive dementia. Abnormal plasma profile and increased VLCFA concentration in the patient's 13-year-old daughter confirm the ALD diagnosis.
The PCR conditions have been optimized to make the process faster and more economical. When short DNA fragments are to be amplified, the time of denaturation, annealing and extension steps can be as short as 1 s each, and the yield of PCR product is still high, sufficient for many types of analysis. The PCR can be done even in a reaction volume as low as 1 microliter. The recommended volume, 2.5 microliters or 5 microliters, allows significant savings in the laboratory budget especially for laboratories which use PCR frequently and on a large scale.
The morphology of the claustrum in Galloway syndrome was investigated. Galloway syndrome is a rare autosomal recessive disease that causes microcephaly and is associated with kidney pathology. The brain examined was small, and the external surface of the hemispheres was lissencephalic, with an abnormal gyrification pattern. The whole cerebral cortex showed severe pathological changes, but the most affected area was the cortex lying on the medial aspect of the temporal lobe, especially the entorhinal cortex. In addition, the paraamygdalar and temporal parts of the claustrum were intensively changed. These results may confirm the opinion that the claustrum is a cortico-dependent structure and that the limbic cortex receives large projection from its ventral parts.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.