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Biomedical subjects

P Kristiansen

Publications and source records attributed to P Kristiansen.

11 recordsLinked to original sources

Cerebral venous thrombosis and Escherichia coli infection in neonates.

AIM: To present a possible association between cerebral venous thrombosis (CVT) and infection with Escherichia coli. METHODS: Four neonates with deep CVT occurring during an E. coli infection are presented. RESULTS: In these patients the thrombotic disease was found by Doppler ultrasonography. The thrombosis involved at least the sagittal sinus and the transverse sinus according to subsequent MRI scans. The E. coli strains did not produce verotoxin or haemolysin. Disseminated intravascular coagulation was not demonstrated. Three patients presented with seizures. At discharge, all of the patients had signs of neurological damage, but two of them have improved significantly since then. None of the patients has had recurrent (venous) thrombosis. CONCLUSION: E. coli infections in neonates may predispose to CVT, a finding that has clinical implications.

Escherichia coli↗

Bilateral renal autotransplantation with direct pyelocystostomy in a patient with frequent disabling nephroureterolithiasis. Case report.

A case with disabling nephroureterolithiasis, initially most frequent from the right side, later also from the left kidney, is presented. Conservative treatment did not improve the condition and bilateral renal autotransplantation with pyelocystostomies was performed. Follow-up so far has been uneventful. In highly selected cases this is a useful alternative treatment.

Cystostomy↗

Perforation of continent caecal reservoir for urine twice in one patient.

Perforation of a continent caecal reservoir, presumably during catheterization, occurred twice in a 64-year-old woman, 52 and 59 months after urinary diversion, during hyperglycemic confusion. Acute overdistension of the reservoir, creating high tension in its wall, with resulting weakness, could have been an underlying cause of the perforation. Awareness of this potentially lethal complication in patients with augmented bladder or continent urinary reservoir is necessary.

Cecum↗

Significance of group B streptococci in urine cultures from males and non-pregnant females.

Over a 2-year period, 1% of 24,000 urine cultures with possible relevant bacteria from males and non-pregnant females greater than or equal to 15 years of age were found to harbour group B streptococci (GBS) in quantities greater than or equal to 10(5) colony forming units (cfu)/ml; a further 0.9% harboured GBS in quantities greater than or equal to 10(4) but less than 10(5) cfu/ml. Patients with GBS in urine were evenly distributed by age. Those with greater than or equal to 10(5) cfu GBS/ml in voided urine more frequently had true bacteriuria (i.e. bacteria in the urine bladder) than did patients with less amounts (p = 0.01) as determined by suprapubic aspiration of 23 patients. One third (3/9) of the aspirated patients with greater than or equal to 10(5) cfu GBS/ml in simultaneously voided urine, had contaminated urine only and no true bacteriuria. The acute symptoms and clinical conditions of 128 patients with greater than or equal to 10(5) cfu GBS/ml urine were studied by matching 128 patients with negative urine cultures (less than 10(2) cfu/ml) and 128 patients with comparable quantity of Escherichia coli. The incidence of acute lower urinary tract symptoms in patients with GBS was greater than that in patients with negative urine cultures (p less than 0.01), and the same as that in patients with E. coli. The incidence of fever was lower in patients with GBS than in those with E. coli (p less than 0.01). The incidence of urinary tract abnormalities was greatest in patients with GBS in urine. No GBS serotype seems to have particular affinity to the urinary tract.

Adolescent↗

Additional lactate dehydrogenase (LDH) isoenzymes in normal testis and spermatozoa of adult man.

Adult human testicular tissue contains up to six previously undescribed lactate dehydrogenase (LDH) isoenzymes in addition to the five LDH isoenzymes normally found and the sixth found in spermatogenic cells and spermatozoa, LDH-X. Additional LDH isoenzymes were also found in spermatozoa but not in seminal fluid or in serum. After electrophoresis one additional LDH isoenzyme of testicular tissue was localized between LDH-1 and LDH-2, two between LDH-2 and LDH-3, two between LDH-3 and LDH-4, and two between LDH-4 and LDH-5. These localizations indicate that the additional LDH isoenzymes are tetramers combining the A and B subunits of the five normal LDH isoenzymes and the C subunit of LDH-X. The additional LDH isoenzymes may be important in the metabolism of spermatogenic germ cells and spermatozoa.

Adult↗

Thrombosis after elective phlebography as demonstrated with the 125 I-fibrinogen test.

The 125I fibrinogen test was used in 54 patients before and daily for 4 to 6 days after phlebography, for evaluating the incidence of post-phlebographic thrombosis. The indication for phlebography was in all cases varicose veins with perforators. A significantly increased fibrinogen uptake was found after phlebography in 4/54 patients in the calf, suggesting development of deep venous thrombosis, which, however, could not be confirmed with plethysmography or thermography. None had clinical signs of deep vein thrombosis. The rather low incidence of post-phlebographic thrombosis compared with other series is discussed.

Adult↗