Biomedical subjects

P Kristufek

Publications and source records attributed to P Kristufek.

6 recordsLinked to original sources

PubMed2000

[Epidemiologic and microbiological aspects of mycobacteriosis in Slovakia--Mycobacterium szulgai].

The first case of mycobacteriosis caused by M. szulgai in the territory of Czechoslovakia was discovered in the year 1979 in southern Slovakia and was published in our and foreign literature in the year 1981. The purpose of this investigation is to describe the epidemiological situation of the diseases caused by M. szulgai in Slovakia and to compared it with the experiences in chosen developed countries, especially focused on the localization of the disease, factors of transmission, mechanism of transmission and other epidemiological characteristics. The methodology of this paper is based upon surveillance of tuberculosis applied on mycobacterioses. During the period of last 20 years two cases of the disease without mutual epidemiological connection were discovered. In contradiction to other mycobacterioses, diseases caused by M. szulgai, have not the tendency to endemic occurrence. The most often transmission factors are contaminated water and soil. Both cases of M. szulgai in Slovakia suffered from pulmonary diseases. Other localization reported in other countries, for example: olecranon bursitis, skin infections, cervical adenitis, osteomyelitis and renal disease were not reported in our country up to now. (Ref. 23.)

Humans↗

PubMed1977

[Rehabilitation of respiration in outbreaks of bronchial superinfection].

The authors analized the effect of reeducation on patients with an exacerbated bronchial stasis and mucostasis. The group studied was composed of 103 patients suffering from chronic bronchitis, with or without pulmonary emphysema, bronchial asthma and bronchiectasis. Examination methods and breathing reeducation methods were briefly reported. Values measured before and after reeducation enabled by comparison the appreciation of this as an independent method. The rates of pulse (P less than 0.005), of breathing (P less than 0.001) and of systolic pressure (P less than 0.05) were influenced favourably by reeducation. The average quantity of sputum per day increased by 69% (P less than 0.001) specially in asthmatic patients, in itself an important improvement. After exercise there was a slight decrease of PaO2 and SaO2, but after 2 hours of rest, improved values for PaO2 (P less than 0.05), SaO2 (P less than 0.05) Raw (P less than 0.05) and SGaw (P less than 0.05) were noted. The transitory decrease was probably due to tired respiratory muscles and auxillary respiratory muscles. Breathing reeducation favourably affected the clinical conditions, the sputum production, mucostasis, blood-gases exchange, and decreased the airways obstruction. For a greater objectivity, different methodological approaches should also be considered.

Adult↗

PubMedDate not supplied

Early detection of airway abnormalities in a selected group of population.

Functional data were collected from 5,746 males from a country region, whose ages ranged from 14 to 65 years. Out of this population we excluded a group of 466 males (9%) who had abnormal results of traditional pulmonary function screening tests (FVC less than 80% reference values or FEV1% FVC less than 70%) and chose a group of 1,092 males (19%) with normal values for the above two parameters but with abnormal forced mid-expiratory flow. In randomly selected persons of the second group we found frequency dependent dynamic compliance (100%), abnormal maximum expiratory flow at 25% of vital capacity (98%), increased residual volume (76%), decreased maximum expiratory flow at 50% of vital capacity (67%), and increased closing capacity (57%); on the contrary static complicane and airway resistance were normal. To account for these results we suppose that measurement of forced mid-expiratory flow, abnormal values of which we obtained in practically one fifth of the experimental population, could represent, in agreement with other reports, a suitable screening test for first or early detection of airway abnormalities.

Adult↗

PubMedDate not supplied

Pulmonary complications in patients with inflammatory bowel disease.

BACKGROUND/AIMS: Between 1996 and 1998 we investigated the occurrence of lung disorders in 82 patients with inflammatory bowel disease (30 patients with ulcerative colitis and 52 patients with Crohn's disease) and a control group of 60 subjects. The aim of our study was to determine the occurrence of pulmonary complications in patients with inflammatory bowel disease, to investigate whether ulcerative colitis or Crohn's disease are connected with a typical lung function disorder, with the inflammatory activity of the disease or if they depend on the presence of other extraintestinal manifestations. METHODOLOGY: We investigated the occurrence of lung disorders in terms of the following parameters: clinical pulmonary symptoms, chest radiography and pulmonary function tests (body plethysmography, pneumotachography, lung transfer capacity for carbon monoxide, and blood gas analysis). RESULTS: Lung function abnormalities were significantly more frequent in patients with inflammatory bowel disease as compared to controls (p<0.001). There was no apparent correlation between these abnormalities and either bowel disease activity or drug administration (sulphasalazine, mesalazine). CONCLUSIONS: Despite the lack of radiological abnormalities, we identified a high incidence of pulmonary function abnormalities (suspicious of interstitial lung disorder) in patients with inflammatory bowel disease; 56.7% of patients with ulcerative colitis and 57.7% of patients with Crohn's disease had reduced lung transfer factor.

Adolescent↗

PubMedDate not supplied

Reference values and modelling of lung function development as a transcendent function of age, body height and mass.

We present new lung function reference values based on an investigation of 1024 healthy subjects aged 6-81 years. The dependent variables, i.e. VC, FEV1, RV, FRC, TLC, PEF, MEF50 and MEF25 are expressed as transcendent functions of age, body height and mass. A single equation covers the age range from 6 to 81 years and reflects certain phenomena such as growth, maturation, ageing, sex differences and the undermass-overmass effect. This allows a more accurate determination of individualized reference values and normal limits.

Adolescent↗

PubMedDate not supplied

Contribution to the problem of occurrence of tuberculosis in patients with systemic lupus erythematosus.

The association of SLE with tuberculosis (TB) was studied in a group of 388 patients with SLE monitored between 1953-1994. TB was diagnosed in 14 patients (3.6%). The occurrence of septic fevers in SLE patients that did not respond to glucocorticoid therapy indicated the possibility of complication with TB. SLE-associated TB included miliary and far-advanced pulmonary and extrapulmonary forms. Three patients from our group died due to myco-bacterial infection and one patient died of active SLE and TB. The treatment was successful in nine patients. Early diagnosis and appropriate management are mandatory in SLE associated TB, which otherwise may have a potentially fatal outcome.

Adolescent↗