Evaluation of two uterotonic medications for the management of the third stage of labor.
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Biomedical subjects
Publications and source records attributed to P Kushtagi.
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INTRODUCTION: The duration of human pregnancy is arbitrarily taken as 280 days (40 weeks). Foetuses are considered to be at high risk once pregnancy goes beyond the expected date of confinement. This study was carried out with the aim of determining the mean gestation age of low-risk pregnancies that went into spontaneous labour and the incidence of adverse outcomes in relation to gestation. METHODS: Low-risk singleton pregnancies admitted in spontaneous labour at a single community hospital in the Udupi district of Karnataka in South India, from December 2002 to December 2003, were analysed for mean gestational age at the onset of spontaneous labour and rates of perinatal complications by gestational age. RESULTS: Among the 1,094 women who went into spontaneous labour, the mean gestational age was 272.1 +/- 9 days. A significantly increased incidence of meconium-stained amniotic fluid beyond 39 weeks of gestation was observed. 783 of 1,094 women (80 percent) had delivered during the period of 261-280 days of pregnancy (period of one standard deviation around the mean gestational age at delivery). There was significant increase in perinatal morbidity indicators and mortality rates once the pregnancy carried beyond 280 days. CONCLUSION: Mean gestational age at the onset of labour for women native to the area of study was 272 days (standard deviation 9 days). Pregnancies beyond a duration of 280 days showed significantly increased perinatal morbidity. It is suggested that there is a need for determining the length of gestation and to compile gestation-wise incidence of meconium-stained amniotic fluid as an indicator of foetal maturity or the undisclosed risk factor, in addition to other neonatal morbidity indicators for different populations.
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The phenomenon of foetal head descent and the effect of station of foetal head at admission on the course of labour were studied on the basis of a prospective partographic study in 100 cases of normal labour. Only 16.9% of nulliparous women had engaged foetal head at admission in labour. Engagement of foetal head occurred during the period of maximum slope of cervical dilatation in nulliparous women and at the onset of deceleration phase in multiparous women. Parturients with unengaged foetal head entered hospital much earlier in labour than those with engaged foetal based. Course of labour was uninfluenced by the degree of engagement of foetal head. However, multiparous women showed faster rate of foetal head descent than nulliparous women (p < 0.001) and women with lesser haemoglobin concentration demonstrated slower rate of descent of foetal head (p < 0.01).
Doppler assessment of umbilical artery waveforms using the peak systolic to end diastolic (S/D) ratio was used to determine if complications associated with impaired trophoblastic invasion of placental bed (i.e. pregnancy induced hypertension and intrauterine growth retardation) could be predicted. Values for S/D ratio of at least 4, 3.5 and 3 at 22-26, 30-32 and > or = 37 weeks gestation, respectively, were found to be better predictors of such complications. Pregnancy-induced hypertension could be predicted in 63% and growth retardation in 60% cases at 22-26 weeks of gestation.
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