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Biomedical subjects

P L Cooperberg

Publications and source records attributed to P L Cooperberg.

At least 19 recordsLinked to original sources
PubMed1992

Sonographic characteristics of the urethrovesical anastomosis in the early post-radical prostatectomy patient.

It is possible that the advent of more aggressive surgical approaches to carcinoma of the prostate, including neoadjuvant and adjuvant therapy, will lead to a higher incidence of pelvic recurrence rates in coming years. A method of sequentially monitoring the region of the urethrovesical anastomosis for early recurrence that is more accurate than digital rectal examination is required. Transrectal ultrasound is an established technique for the preoperative assessment of prostate cancer. It has also been used postoperatively to guide a biopsy needle into palpably suspicious areas at the urethrovesical junction or for random biopsies in patients with elevated prostate specific antigen levels. However, the sonographic anatomy of the postoperative urethrovesical junction has not previously been described. In this prospective study we analyze the transrectal sonographic characteristics of the neoanatomy in 30 patients, all within 3 months following surgery for clinically intracapsular disease. We describe features of the neoanatomy, such as anterior tissue nodules and anastomotic rings. Because of distinct variations in the neoanatomy of different patients we recommend early postoperative transrectal biplanar sonography to establish a baseline image for each individual case. This would be useful for later comparison and may prevent a false positive scan on subsequent followup studies.

Adenocarcinoma↗
PubMed1992

Pancreatic duct obstruction treated with percutaneous antegrade insertion of a metal stent: report of two cases.

Expanding metal stents were used to treat symptomatic pancreatic duct obstruction in two patients with chronic pancreatitis. Both patients initially underwent percutaneous external pancreatic duct drainage and then had metal stents inserted for internal drainage. Both patients remained asymptomatic, and the stents were patent during short-term follow-up periods of 6 and 9 months, respectively. Percutaneous insertion of metal stents, which can be performed to treat pancreatic duct obstruction after a trial of external drainage has been shown to relieve the patient's symptoms, should be considered as an alternative to endoscopic stent placement or surgical drainage.

Aged↗
PubMed1992

Testicular microlithiasis: sonographic and clinical features.

Eleven cases of bilateral diffuse microlithiasis of the testes were evaluated sonographically. The presence of testicular microlithiasis was coincidental to the presence of testicular neoplasms (n = 2), nontesticular malignant lesion in the abdomen or chest (n = 2), subfertility (n = 2), varicocele (n = 1), epididymitis (n = 1), testicular maldescent (n = 1), scrotal trauma (n = 1), and transient scrotal pain (n = 1). Clinical follow-up suggested that testicular microlithiasis is an asymptomatic nonprogressive condition. Sonographic examination of testicular microlithiasis shows diffuse hyperechoic nonshadowing foci measuring 1-2 mm in diameter throughout both testes. The diagnosis of testicular microlithiasis was pathologically proved in five cases. In six cases, the diagnosis was made on the basis of the sonographic appearance (n = 6), clinical information and follow-up (n = 6), and radiologic demonstration of testicular microcalcifications (n = 3). The sonographic appearance of testicular microlithiasis is specific, and we believe that biopsy or orchiectomy in these cases is unnecessary.

Adult↗
PubMed1991

Transurethral resection of prostatic abscess under sonographic guidance.

Transrectal ultrasound may establish the diagnosis of prostatic abscess in an ambiguous clinical setting. Transurethral resection (deroofing) is the treatment preferred by many clinicians, yet intraoperative complete abscess obliteration may be difficult to confirm endoscopically. We report on a patient with a complex prostatic abscess endoscopically resected under transrectal ultrasound guidance. Adequacy of treatment was proved pathologically.

Abscess↗
PubMed1991

Sonographic visualization of the ureter in pregnancy.

We describe a method of differentiating physiological from pathological dilatation of the renal collecting system in pregnant patients. In physiological hydronephrosis the dilated ureter extends down only to the level of the common iliac artery. In 2 patients with distal ureteral stones a dilated ureter was visualized past the vessels. To determine the frequency and reliability of visualizing the ureters in pregnant patients 105 consecutive asymptomatic pregnant patients were examined. Hydronephrosis was found in 83 kidneys in 59 of the patients. The dilated ureter was visualized in 64 of the renal units. The anatomy was well demonstrated by color flow Doppler scanning and in all of these cases the dilated ureter was seen to taper where it crossed the common iliac artery. These results suggest that the presence of a dilated ureter past the iliac artery is strong evidence for pathological distal ureteral obstruction in pregnancy.

Adult↗
PubMed1991

Differentiation of detached retina and vitreous membrane with color flow Doppler.

The sonographic criteria for diagnosis of retinal detachment and vitreous membranes are well established, and in most cases a diagnosis can be made. However, in difficult cases, differentiation between the two may be difficult. In this study the use of high-resolution color flow Doppler was evaluated for differentiating between retinal detachments and vitreous membranes. Sonographic evaluation, including color flow Doppler, was performed in 25 symptomatic eyes. Seven eyes had areas of retinal detachment, all of which had detectable blood flow within at least a portion of the detached retina. Fifteen eyes had vitreous hemorrhages or membranes in which no flow was detected. Two diabetic patients with vitreous membranes and no retinal detachment did have flow detectable within the neovascular membranes. Another patient, who had a complete choroid detachment after surgery, demonstrated good flow within the area of detachment. It is concluded that in difficult cases high-resolution color flow Doppler can enable differentiation of an area of retinal detachment from a vitreous membrane in a patient without diabetes.

Adolescent↗
PubMed1991

Total occlusion of the common carotid artery with patent internal carotid artery. Identification with color flow Doppler imaging.

With common carotid artery occlusion there is usually no flow in the distal vessels. However, flow to the ipsilateral internal common carotid artery may be maintained by collateral vessels. Nine of 1100 patients referred for carotid duplex sonography were found to have occluded common carotid arteries. Five of these patients had collateral circulation with reconstitution of flow via the external carotid artery. The color Doppler sonograms of three representative patients are presented. There was antegrade flow in the internal carotid artery with retrograde flow in the external carotid artery.

Adult↗
PubMed1990

Color and spectral Doppler mirror-image artifact of the subclavian artery.

The mirror-image artifact, which has been previously described in gray-scale sonographic imaging, is also readily visualized with both spectral and color Doppler flow imaging. In 10 consecutive healthy subjects, a mirror image of the subclavian artery was readily apparent at gray-scale, spectral Doppler, and color Doppler sonography. An experimental in vitro model was constructed to demonstrate that the lung apex, which is located immediately posterior to the subclavian artery, acts as the highly reflective acoustic interface to form this artifact. Knowledge of the presence of the mirror-image artifact should be helpful to the radiologist and sonographer in avoiding misinterpretation of this important pitfall in both spectral and color Doppler flow imaging of the subclavian region, where there is a plethora of branching vessels.

Humans↗
PubMed1989

Color flow duplex screening of infrainguinal grafts combining low- and high-velocity criteria.

The aim of this prospective study was to evaluate the ability of duplex ultrasonography to identify infrainguinal grafts at high risk for failure. The criteria used identified low flow by low peak systolic velocity (less than 45 cm/s) and stenosis by high velocity (greater than 300 cm/s) or by velocity at the stenosis three times the velocity in the adjacent normal graft. A total of 114 patent grafts were scanned and compared with concurrent angiograms. Duplex scanning correctly identified 18 high-risk grafts by low-flow criteria and an additional 21 by stenosis criteria. There was one false-negative finding (sensitivity 98 percent). The velocity ratio of the stenosis to the adjacent graft was useful in estimating the degree of stenosis. Color flow duplex imaging reduced examination time through visual feedback by highlighting the graft and areas of high velocity. These results indicate that color flow duplex scanning, combining low- and high-peak systolic criteria, is a very sensitive screening test in the early detection of failing grafts.

Blood Vessel Prosthesis↗
PubMed1989

Combined biopsy techniques: an approach to the diagnosis of prostatic malignancy.

We present our results of 3 biopsy techniques applied to each of 62 patients with clinically suspicious prostatic nodules. Transrectal digitally guided and sonographically guided transperineal fine needle aspiration biopsies were followed by digitally guided transperineal core biopsy in all cases. Adenocarcinoma was confirmed in 25 patients by 1 or more of these techniques. Our results indicated that 7 of 25 cancer cases (28 per cent) were detected by only 1 of 3 applied methods of biopsy and 56 per cent were detected by all 3 techniques. When a clinical suspicion of malignancy remains after a negative aspiration or core biopsy consideration should be given to alternative forms of biopsy to establish a diagnosis.

Adenocarcinoma↗
PubMed1989

Palpable prostatic nodules: comparison of US and digital guidance for fine-needle aspiration biopsy.

This study was undertaken to evaluate the use of transrectal sonographically guided fine-needle aspiration biopsy and to compare sonographic with digital guidance for biopsy. In 62 patients in whom prostatic carcinoma was suspected at digital rectal examination, fine-needle aspiration biopsies were performed transperineally under sonographic guidance and transrectally under digital guidance. These patients had 89 nodules, 73 of which were sampled with both techniques. Malignant cells were obtained under digital guidance in 17 of 73 nodules (23%) and under sonographic guidance in 16 (22%). An additional seven nodules, which were not seen sonographically, were sampled under digital guidance and proved to be negative. In nine other nodules that were nonpalpable and evident only with sonography, malignant cells were obtained under sonographic guidance in three. These findings indicate that sonographic guidance for fine-needle aspiration biopsy is as good as digital guidance for palpable lesions.

Adult↗
PubMed1989

Color-flow Doppler and conventional duplex scanning of the carotid bifurcation: prospective, double-blind, correlative study.

Color-flow Doppler is a useful adjunct in duplex sonography of peripheral vessels. This study was undertaken to see if color-flow Doppler could give semiquantitative information about the degree of stenosis at the origin of the internal carotid artery. The factors evaluated on color flow are the width of the lumen as estimated from the color-flow image relative to the width of the vessel, the degree of turbulence (evidenced by the mosaic pattern), and the pulse-repetition frequency necessary to prevent aliasing. A double-blind comparison with conventional duplex scanning in 146 carotid bifurcations in 74 patients was carried out. In 91%, the color-flow assessment was in complete agreement with the duplex assessment. In the remaining 9%, the color flow differed from the duplex by only one stenosis group, and the distributions of over- and under-estimation were equal. These results showed comparable assessment of the degree of stenosis with conventional duplex and color Doppler technology.

Adult↗
PubMed1989

Gallstone recurrence after cholecystolithotomy.

Surgical cholecystostomy is performed often at our institution for emergent management of acute calculous cholecystitis in high-risk elderly patients. Gallstones are removed either during surgery or by subsequent radiologic manipulation. Most such patients do not undergo subsequent cholecystectomy. The frequency of gallbladder stone and/or biliary symptom recurrence was studied in 63 patients who had undergone successful cholecystolithotomy. Follow-up examinations in 48 of these patients, performed at a mean of 18 +/- 12 months after surgery, showed recurrence of gallstones in 13 patients (27%). This included 12 of 38 patients who had follow-up sonograms and one of two cadavers that underwent autopsy. None of eight patients who had a subsequent cholecystectomy had recurrent stones. Two of 17 patients studied within 1 year of cholecystolithotomy had recurrent calculi, as did six of 21 patients studied at 1-2 years, four of five patients studied at 2-3 years, and one of five patients studied at 3-4 years. Biliary symptoms were assessed in 46 of the 48 patients who had follow-up examinations (two patients died) and in the 15 other patients who had undergone successful cholecystolithotomy. Recurrent or residual symptoms were present in seven (11%) of 61 patients, including three of the 13 patients with recurrent calculi. Six of these seven patients underwent further hospital treatment. These results confirm the anticipated high frequency of stone recurrence after cholecystolithotomy. However, because most patients with recurrent stones were asymptomatic, routine interval cholecystectomy may not be necessary.

Acute Disease↗
PubMed1989

Ultrasonography in acute appendicitis.

Although the disease is common, the clinical diagnosis of appendicitis remains difficult. Since the indications for surgery are imprecise, greater diagnostic accuracy depends on the development of other methods for detection of inflammatory changes in the appendix. During eight months, high-resolution ultrasonography (US) was used for the evaluation of 37 patients with clinically suspected appendicitis. The US findings were confirmed by surgery or pathology and clinical follow-up. With a sensitivity of 0.87, a specificity of 0.95, and an accuracy of 0.92, high-resolution US is a valuable adjunct in the evaluation of appendicitis.

Acute Disease↗
PubMed1989

Hemangioma of the liver: characteristics exhibited on a 0.15 Tesla scanner.

Twenty-two liver hemangiomas, initially diagnosed using ultrasonography, were imaged with a Picker 0.15 Tesla super-conducting scanner in order to (1) determine the reliability of spin-echo (SE) signal intensity measurements and the calculated T1 and T2 values of both normal tissue and hemangiomas and (2) assess the characteristics of hemangiomas as visualized by a low-field magnetic resonance imaging unit. Reproducible measurements of T1 values and signal intensities are possible (r = 0.93-0.99) but T2 values are less reproducible (r = 0.79) and more variable. T1 values provide the best discrimination between hemangiomas and normal liver (99% successful classification) followed by the SE signal intensity differences (94%). Signal intensity ratios and contrast-to-noise ratios of lesions compared with liver are similar to those of other studies. Most small hemangiomas exhibit homogeneous signal intensity but larger lesions can be nonhomogeneous.

Adult↗
PubMed1988

Early hydronephrosis following aortic bifurcation graft surgery: a prospective study.

The true incidence and natural history of ureteral obstruction following reconstructive vascular surgery have not been determined previously. A series of 101 patients undergoing aortofemoral and aortoiliac reconstructive surgery were studied prospectively to determine the frequency of hydronephrosis in the first postoperative year. Serial real-time ultrasound examinations were performed preoperatively as well as at 1 week, 3 months and 1 year postoperatively. Ninety-three patients completed the study, with a total of 181 kidneys at risk. Hydronephrosis of mild to moderate degree developed in 15 kidneys (8 per cent) in 11 patients (12 per cent). All patients were asymptomatic, and the obstruction resolved spontaneously in 10 of 11 patients, including 9 within 3 months of onset. Only a single case persisted at 1 year. This study confirms that the hydronephrosis that occurs within the first year after aortic bifurcation graft surgery is not uncommon but it is rarely of clinical significance in the asymptomatic patient.

Aorta, Abdominal↗