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Biomedical subjects

P L Doering

Publications and source records attributed to P L Doering.

45 records · Page 3Linked to original sources
PubMed1979

Prolonging paracervical block anesthesia: addition of dextran to 2-chloroprocaine.

Forty parturient women received paracervical block (PCB) anesthetics during labor with 2-chloroprocaine (2-CP) and epinephrine in either normal saline or dextran. Thirty-six patients were though to have adequate anesthesia. Nineteen patients who recived 2-CP in saline had a mean duration of anesthesia lasting 55.4 min; one fetus developed post-PCB bradycardia. Seventeen patients who received 2-CP in dextran had a mean duration of anesthesia lasting 72.7 min; no fetal bradycardia was observed following PCB. Neonatal depression, expressed by 1 and 5 min Apgar scores below seven, was not observed in either group. The addition of dextran to 2-CP significantly prolongs the duration of PCB anesthesia and does not appear to compromise the fetus. The pain relief provided by a single PCB with 2-CP in dextran is still relatively short and would not persist throughout the active phase of labor in most parturient women.

Adolescent↗
PubMed1979

Nonpharmacy outlets providing prescription medications to ambulatory patients.

Nonpharmacy outlets providing prescription medication to ambulatory patients in Alachua County, Florida, were investigated. The sample included 16 ambulatory clinics and 44 dispensing physicians. The types of medications dispensed and dispensing procedures used by these outlets are described. The magnitude of prescription drug dispensing in ambulatory clinics and physicians' offices was far greater than was initially expected. Numerous drug-related problems were identified within these outlets, including a failure to comply with state and federal laws, inadequate drug control and storage, and inadequate patient medication records. Practicing pharmacists should consider the possibility of their patients receiving medication from similar outlets in evaluating therapies for appropriateness and interactions. In addition, such centers have apparent need for pharmacy consultation services to ensure adherence to the principles of responsible pharmaceutical services.

Adult↗
PubMed1978

The extent and character of drug consumption during pregnancy.

One hundred sixty-eight obstetrical patients' conditions were monitored prospectively throughout the prenatal, perinatal, and postpartum periods to obtain data on maternal drug consumption. In the prenatal period, all patients received at least two different drug products: 93.4% received five or more, while one patient reported taking 32 different products. The average number of drug products used in the prenatal period was 11.0. The mean perinatal exposure in patients undergoing vaginal delivery was 7.0. Analysis by therapeutic category was performed. Information gathered confirms the fact that pregnant women do take a large number of different types of medications, the consequences of which remain unknown.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

Effect of common over-the-counter medications on blood alcohol levels.

OBJECTIVE: To assess the clinical and legal significance of the potential pharmacokinetic interaction between common over-the-counter (OTC) medications and alcohol that may result in increased blood alcohol levels (BALs). DATA SOURCES: A MEDLINE search (1966-February 2000) of English-language articles was performed using the terms aspirin, acetaminophen, histamine (H2)-receptor antagonist, ethanol, and blood alcohol level and then supplemented by a bibliographic review of relevant articles. STUDY SELECTION AND DATA EXTRACTION: Two H2-receptor antagonist studies using methodologies representative of other published trials and a meta-analysis of 24 H2-receptor antagonist trials were chosen for detailed review. All identified studies examining aspirin and acetaminophen were addressed. DATA SYNTHESIS: More than 30 studies have examined the potential interaction between OTC drugs and blood alcohol. Because this issue has important medical and legal implications for patients, prescribing physicians, and pharmaceutical manufacturers, a critical analysis of the literature addressing this potential interaction is presented. CONCLUSIONS: Numerous factors arguing against a clinically significant interaction were identified. First, data from the relevant studies cannot be extrapolated to the general population because of the multitude of variables that determine an individual's BAL. Also, a publication bias for small studies (< or = 10 subjects) finding a statistically significant increase in peak BAL was observed. In addition, study results supporting an increase in BAL were often irreproducible when these trials were repeated under similar conditions. Finally, although some studies detected statistically significant increases in peak BAL, these changes were often clinically irrelevant.

Adult↗
PubMedDate not supplied

GHB: an important pharmacologic and clinical update.

Gamma-hydroxybutyrate (GHB) intoxication is a significant cause of morbidity and mortality in patients taking the drug for recreational purposes. Due to the recent increase in emergency room visits, hospital admissions, and deaths, it has become necessary to re-examine the pharmacology, pharmacokinetics, pharmacodynamics, clinical manifestations, and potential adverse effects associated with GHB use. We present an important pharmacologic and clinical update on GHB.

Anesthetics, Intravenous↗