Randomised clinical trials in general practice.
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Family Practice↗
Biomedical subjects
P L Jonker
Publications and source records attributed to P L Jonker.
Antibiotic prophylaxis in abdominal hysterectomy, with special reference to the duration of the prophylaxis.
Two consecutive open studies were performed of the efficacy of a prophylactic cefuroxime/metronidazole combination in abdominal hysterectomy. The first group received a 24-h regimen, the second group a single pre-operative dose. The incidence of post-operative wound infections and urinary tract infections were similar in both groups [wound infections in 1/75 versus 2/84 patients (NS), urinary tract infections 4/75 versus 3/84 patients (NS), respectively, in the 24-h group and single-dose group]. No significant differences in other parameters, such as pyrexia and duration of post-operative hospitalization, could be detected.
Adult↗
Menkes' kinky hair disease. I. Comparison of classical and unusual clinical and biochemical features in two patients.
Two patients with Menkes' kinky hair disease were examined. Both showed the characteristic clinical features of this disease in combination with a low plasma-copper level. However, for one of them, studies with 64Cu provided clues that the copper was handled in a way unusual for a Menkes patient, viz., incorporation of 64Cu into ceruloplasmin during an oral 64Cu-loading test and abnormal behavior of skin fibroblasts in in vitro experiments. A comparison with brindled mice and some clinical aspects, viz., the age at death, the quality of the hair and the macrocephaly, of both patients are discussed.
Brain Diseases, Metabolic↗
A multicentre, randomized comparative study of 500 mg versus 1,000 mg ceftazidime t.d.s. for treatment on gram-negative infections.
A multicentre, randomized study was performed to compare the clinical and bacteriological efficacy of 500 mg ceftazidime i.v. t.d.s. with 1,000 mg ceftazidime i.v. t.d.s. for treatment of hospitalised, non-compromised patients with gram-negative infections. The study was conducted in ten hospitals in The Netherlands. Hospitalised patients with a suspected gram-negative lower respiratory tract infection, complicated urinary tract infection or septicaemia were included. Excluded were patients with neutropenia, limited life expectancy, or severe renal insufficiency as well as those on antibiotics in the 48 h prior to entry. Ceftazidime was administered via an intravenous infusion every 8 h. For patients with moderately impaired renal function the frequency was reduced to 12 h. Treatment was continued for as long as clinically indicated. Clinical response (cure, improvement or failure) and bacteriological response (elimination, persistence or non-evaluable) were assessed primarily by the investigator. Final assessments were made by a panel of experts without prior knowledge. In total 127 patients were randomized, 64 patients to the 500 mg group and 63 to the 1,000 mg group; 47 patients were excluded from evaluation, usually due to an incorrect diagnosis prior to randomization. Ultimately 37 patients of the 500 mg group and 43 patients of the 1,000 mg group were available for evaluation. Between these two groups of evaluable patients there were no significant differences in baseline characteristics, types of infection, isolated bacterial pathogens or treatment characteristics.(ABSTRACT TRUNCATED AT 250 WORDS)
Adolescent↗