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Biomedical subjects

P L Levick

Publications and source records attributed to P L Levick.

9 recordsLinked to original sources
PubMed2002

Resistin, central obesity, and type 2 diabetes.

Resistin, an adipocyte-derived cytokine, causes insulin resistance and glucose intolerance in mice. We investigated whether resistin expression was higher in human abdominal adipose tissue than other adipose tissue depots. We extracted RNA from 32 adipose tissue samples (13 subcutaneous abdominal, seven omentum, six thigh, and six breast). Quantitative PCR was used to determine resistin mRNA expression. Resistin mRNA concentrations were similar in both the subcutaneous abdominal and omental depots. The abdominal depots showed a 418% increase in resistin mRNA expression compared with the thigh. Increased resistin expression in abdominal fat could explain the increased risk of type 2 diabetes associated with central obesity.

Adipose Tissue↗
PubMed1994

Tissue-expanded visor flap in burn surgery.

Severe postburn scarring of the lower face in the adult male may cause loss of mustache and beard in addition to other complications. The resulting unacceptable boyish appearance in 3 such patients was treated with tissue-expanded visor flap reconstruction. Complications, which were few, minor, and temporary, included moderate postoperative hematoma, hair-bearing skin loss in the region of the sideburns, and hair growth in an unwanted direction. The flap is safe to perform, with adequate blood supply, and achieved the goal of the operation, which is the restoration of a masculine appearance. The major advantage of this procedure is that the donor site morbidity and alopecia associated with the classic visor flap is virtually eliminated.

Adult↗
PubMed1991

Treatment of full skin thickness burn injury using cultured epithelial grafts.

This report presents the experience gained from 26 patients treated with autogenic cultured epithelial grafts (auto-CEG). All auto-CEG were applied to wounds clinically defined as full skin thickness injury. In total 89 separate sites were grafted. The overall estimate of 'take' ranged from 0 to 98 per cent with a mean value of 15 per cent. The highest level of 'take' (43 per cent) was observed when auto-CEG were applied to wounds which had been previously covered with allogenic split-thickness skin grafts. An increased incidence of wound colonization with pathogenic species of bacteria corresponded with a decreased graft 'take'. Ps. aeruginosa and Staph. aureus were found to be present on 32.6 per cent and 60.5 per cent of wound swabs respectively, where 10 per cent or less 'take' of auto-CEG was seen, indicating that bacterial infection is in part responsible for graft failure. However, in 20.9 per cent of such instances, no growth of bacteria was detected, perhaps suggesting that certain wound beds may not present the correct physical environment necessary to support proliferating epithelial cells isolated from their underlying dermal component.

Adolescent↗
PubMed1987

Metastatic basal cell carcinoma.

A case of metastasizing basal cell carcinoma is presented. Although primary surgical excision appeared complete, local recurrence continued over the following 5 years terminating in metastases to lungs, kidneys, bones and lymph nodes.

Bone Neoplasms↗
PubMed1986

Use of tissue expanders after burns and other injuries.

During the first year of use of tissue expansion at the Birmingham Accident Hospital, 24 patients had expansion procedures at 29 sites. Most of these were to revise burn scars. A number of complications occurred and five procedures were abandoned. The advantages and problems of the technique are discussed.

Adolescent↗