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P L Magistretti

Publications and source records attributed to P L Magistretti.

6 recordsLinked to original sources
PubMed1983

Single-photon emission computed tomography. A method of measuring cerebral blood flow in three dimensions (preliminary results of studies in patients with epilepsy and stroke).

The recent development of single-photon emitting radiopharmaceuticals that reflect cerebral blood flow has introduced a new era for the useful application of nuclear medicine to the investigation of neurological disease. Using 123I labelled N-isopropyl-p-iodoamphetamine, we have performed emission-computed tomographic scans of the brain in several clinical settings. These studies display cross-sectional maps of cerebral blood flow and promise significant clinical utility in a variety of brain diseases. In the eight patients with epilepsy, the scans showed good localization of the abnormal foci, and correlated well with the findings at operation in the five patients who were submitted to surgery. All 10 patients with stroke had abnormal scans, and the abnormalities in cerebral blood flow were frequently more extensive than the lesions seen on the transmission-computed tomographic scan. This initial experience leads us to anticipate an increasing role in clinical neurology for single-photon emission computed tomographic scans of cerebral blood flow.

Adolescent↗
PubMedDate not supplied

Assessment of regional cerebral blood flow (rCBF) in stroke using SPECT and N-isopropyl-(I-123)-p-iodoamphetamine (IMP).

In this study we assessed regional cerebral blood flow in patients with signs and symptoms of acute stroke using single-photon emission computed tomography (SPECT) and N-isopropyl I-123 p-iodoamphetamine (IMP). Twenty-five patients with acute cerebral infarction had both IMP brain perfusion studies and CT scans performed within one week of each other; 22 had positive and three had negative perfusion studies. Of the 22 patients who had positive perfusion studies, six had negative CT studies initially. In the 16 patients who had abnormal CT studies, eight of the studies depicted areas of edema that were smaller than the perfusion deficits noted on the IMP studies and eight had areas of edema that were approximately equal in size to the perfusion defect. Of the three patients with normal IMP studies, two had normal CT studies and one had a positive CT study showing a 3-mm lacunar infarction. Using eight control patients, mean count rates per tissue volume normalized for the injected dose was calculated. Similarly, the quantitative data from regions of interest in the stroke patients were calculated and compared to the control patients or to a normal region in the uninvolved hemisphere in the same patients. SPECT with IMP was used to assess regional brain perfusion in acute cerebral infarction. Perfusion abnormalities were seen in our patients when the CT scan was normal, and quantitative data could be used to approximate regional cerebral blood flow in these patients when compared to the normal patient population.

Amphetamines↗
PubMedDate not supplied

Brain imaging with emission computed tomography and radiolabeled amines.

The noninvasive measurement of regional cerebral blood flow in man has been limited to expensive and specialized instrumentation available in only a few facilities throughout the world. Radiolabeled amines, such as I-123 iodoamphetamine, are lipophilic compounds, which are extracted by the brain proportional to blood flow. Scintigraphic maps of regional cerebral blood flow can therefore be obtained using commercially available radionuclides and standard single photon emission computed tomography instrumentation. I-123 iodoamphetamine imaging, therefore, permits the detection and assessment of altered perfusion in neurologic diseases, such as cerebral infarction and epilepsy. This physiologic information complements the anatomic and morphologic information provided by transmission computerized tomography.

Amines↗