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Biomedical subjects

P L McLain

Publications and source records attributed to P L McLain.

8 recordsLinked to original sources
PubMed1985

The quality of emergency room radiograph interpretations.

Primary care physicians often make patient management decisions based in part on their own interpretations of radiographs. This important area of clinical decision making has not been previously analyzed in the literature. In this series of 294 consecutive radiographs from rural practice, interpretative disagreement between primary care providers and backup radiologists occurred 9.2 percent of the time, a discordance rate similar to that seen among radiologists in other studies. Although a majority of the films for which interpretative disagreement occurred had potential implications for influencing patient management, in only seven cases did actual case management vary from appropriate norms. Follow-up of cases where interpretative disagreement occurred revealed that in only two cases did unsatisfactory outcomes occur. Primary care physicians can provide high-quality radiographic interpretations that, when coupled with clinical information, yield extremely low rates of error or potential for poor patient outcomes.

Bone and Bones↗
PubMed1966

Glucose metabolism during ontogeny of intestinal active sugar transport in the chick.

1. Glucose transport, uptake, utilization, and lactate production by intestinal slices from embryos and young chicks have been determined by means of the in vitro tissue accumulation method. Changes in these parameters with age, after feeding, and in the presence of phlorrhizin have been measured, in most cases, under both aerobic and anaerobic conditions.2. The embryonic intestine, 3 days before hatching, took up and utilized only a negligible quantity of glucose from the incubating medium and net lactate production was limited. The transport and utilization of exogenous sugar thus seem to be minimal at this age.3. On the day of hatching, the intestine concentrated and utilized glucose, and lactate production was significant as was the inhibition of glucose uptake by phlorrhizin. This capacity to metabolize exogenous sugar appears to be consequent to onset of function of the sugar transport mechanism just before hatching.4. At 2 days of age intestinal slices concentrated and utilized more glucose than at 0 days of age, if the chicks were not fed. After eating, glucose transport was decreased while lactate production was enhanced. Feeding schedules thus influence sugar transport and metabolism by the young chick intestine.5. The metabolic parameters measured showed essentially the same relationships in intestinal slices from 8- and 36-day-old chicks as in 2-day-old birds. Although there were indications that intestinal maturation continues well into post-natal life, the most striking changes in functional capacity, observed in these studies, occurred during the several days around hatching.

Animals↗