Biomedical subjects

P L Volegov

Publications and source records attributed to P L Volegov.

5 recordsLinked to original sources

PubMed2006

Ultra-low field NMR measurements of liquids and gases with short relaxation times.

Interest in nuclear magnetic resonance measurements at ultra-low magnetic fields (ULF, approximately microT fields) has been motivated by various benefits and novel applications including narrow NMR peak-width, negligible susceptibility artifacts, imaging of samples inside metal containers, and possibility of directly imaging neuronal currents. ULF NMR/MRI is also compatible with simultaneous measurements of biomagnetic signals. However the most widely used technique in ULF NMR-prepolarization at high field and measurement at lower field-results in large transient signals which distort the free induction decay signal. This is especially severe for the measurement of signals from samples and materials with short T1 time. We have devised an approach that largely cancels the transient signals. The technique was successfully used to measure NMR signals from liquids and gases with T1 in the range 1-4 ms.

Algorithms↗

PubMed2005

On concomitant gradients in low-field MRI.

Growing interest in magnetic resonance imaging (MRI) at ultra-low magnetic fields (ULF, approximately muT fields) has been motivated by several advantages over its counterparts at higher magnetic fields. These include narrow line widths, the possibility of novel imaging schemes, reduced imaging artifacts from susceptibility variations within a sample, and reduced system cost and complexity. In addition, ULF NMR/MRI with superconducting quantum interference devices is compatible with simultaneous measurements of biomagnetic signals, a capability conventional systems cannot offer. Acquisition of MRI at ULF must, however, account for concomitant gradients that would otherwise result in severe image distortions. In this paper, we introduce the general theoretical framework that describes concomitant gradients, explain why such gradients are more problematic at low field, and present possible approaches to correct for these unavoidable gradients in the context of a non-slice-selective MRI protocol.

Algorithms↗

PubMed2004

Simultaneously detected biomagnetic signals and NMR.

We have obtained 1H NMR spectra simultaneously with high temporal resolution biomagnetic signals such as the magnetocardiogram (MCG) and magnetomyogram (MMG). The NMR spectra are acquired at measurement fields of 2-50 microT, with corresponding proton Larmor frequencies of 80-2000 Hz. Our measurements demonstrate a method suitable for MR imaging with concurrent measurement of biomagnetic signals that can provide sub-millisecond temporal resolution. The narrow line widths, reduction in susceptibility noise and enhanced spectral resolution at ultra low fields provide a new and extremely sensitive measurement method that may enable direct imaging of biological currents by detecting the phase or frequency shifts produced by magnetic fields arising from those currents. The results of our simultaneous measurements of NMR with MCG and MMG are compared to results from a current phantom to investigate the exciting potential of direct MRI of bioelectric currents.

Electrocardiography↗

PubMed2004

Forward model theoretical basis for a superconducting imaging surface magnetoencephalography system.

A novel magnetoencephalography (MEG) system was designed at Los Alamos National Laboratory (LANL) that incorporates a helmet-shaped superconductor in order to increase the signal to noise ratio. The magnetic field perturbations caused by the superconducting surface must be included in the forward physics for accurate source localization. In this paper, the theoretical basis for the forward model that calculates the field of any magnetic source in the presence of an arbitrarily shaped superconducting surface is presented. Appropriate magnetic field integral equations are derived that provide a description of the physics of the forward model. These equations are derived starting from Maxwell's equations in the presence of inhomogeneous media, with the appropriate boundary conditions for a superconductor. A discretized version of this equation is then compared with known analytic solutions for simple superconducting surface geometries.

Algorithms↗

PubMedDate not supplied

[The measurement of scattering radiation in the radiation control of x-ray offices].

A procedure for measuring the power of an ambient and goal-oriented equivalent scattered radiation dose in the radiation control of X-ray rooms. The procedure is based on the concept of the effective solid angle of a dosimeter directivity diagram. The plots of the angular response of a S2010 selective X-ray dosimeter for studying the radionuclides 119Sn, 241Am, 57Co are exemplified. The scaling factors for dosimetric reading for isotropic and nonuniform fields of radiation were calculated from the obtained values of effective angular solid angles (0.7, 0.8, 1.2 pi).

Humans↗