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Biomedical subjects

P L Weldy

Publications and source records attributed to P L Weldy.

7 recordsLinked to original sources
PubMed1982

The use of microfiche in testing clinical judgment.

This paper reports an investigation of the use of microfiche to replace other more bulky clinical materials in testing clinical judgment. Twenty-three students were administered two versions of tests of clinical judgment (micro-fiche and nonmicrofiche) regarding the treatment of partial edentulism. Each student served as both experimental subject and control. Results indicated that under the conditions of testing used, students preferred the nonmicrofiche version of the test. However, there was no significant difference in time of administration or grades resulting from the microfiche medium. Whether the test was given first or fourth in a series of five made a difference in time to take the test (p less than .01), and in the grade received (p less than .01). Tests taken in the first position took more time to complete and resulted in a higher grade. The rate of agreement in grading between the first and second grading session was 70 percent.

Clinical Competence↗
PubMed1982

Analysis of disagreement in the evaluation of clinical products.

This paper reports an analysis of factors that reduce agreement in clinical evaluation. Four instructors representing different restorative departments met regularly over a four-month period to study the evaluation process. Each participant selected a task from his discipline, identified critical errors made in performing the task, produced these errors in models and extracted teeth, and developed criteria and checklists to aid in categorizing and counting the errors. In weekly sessions the models were evaluated, and judgments were compared. Factors that reduced agreement were identified, discussed, and listed. In some sessions ongoing evaluation was reported orally, tape-recorded, and analyzed to elucidate the underlying mental processes. Analysis indicated that agreement was reduced by 16 factors, including unclear rules, the faculty member's memory, unstandardized aids to judgment, inconsistent observational methods, differences in ability, and differing tendencies to leniency.

Clinical Competence↗
PubMed1979

Establishment of persistent infection by parainfluenza virus type 3: role of a syncytium inhibitor.

A strain of parainfluenza virus type 3 (para 3) that had undergone a series of undiluted passages failed to produce syncytia when inoculated on to Vero cells at a high m.o.i. The strain repeatedly produced stable persistent infections. Persistently infected cells were resistant to superinfection by homologous virus, showed the presence of virus-specific antigen and shed low quantities of infectious virus into the supernatant fluid. The undiluted passage parainfluenza virus type 3 strain produced a substance that inhibited syncytium formation by homologous virus and by measles virus but appeared to have no effect on virus replication. This inhibitor had no demonstrable effect on unrelated viruses, including some that produced syncytia. It had a mol. wt. between 3500 and 14000, was acid- and heat-labile, and was inactivated by anti-para 3 serum.

Animals↗
PubMed1977

Effect of zinc on peritoneal macrophages in vitro.

Rat peritoneal macrophages incubated in a medium with 10% autologous serum showed 50% inhibition of O2 consumption by 0.4 mM zinc only when activated by yeast. Zinc ions had no effect on resting macrophages. The inhibitory efficiency of zinc depended on the ratio of yeast particles to macrophages; with more activated cells, the inhibition was less. The multiple-shaped intact macrophages changed into rounded cells in the presence of 0.1 and 0.5 mM Zn2+ as shown by photomicrography and scanning electron microscopy. When the incubation medium was replaced by zinc-free medium, cells recovered and became irregularly shaped. The reversibility of zinc effect on cell morphology corresponded with uptake and release of zinc by macrophages. The presence of serum in the medium interfered with the magnitude of zinc uptake by macrophages. We conclude that besides already reported effects of zinc on mast cells, platelets, and granulocytes, zinc ions also inhibit some functions of macrophages.

Animals↗