Aperistaltic ureter in upper urinary tract infection--cause or effect?
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Animals↗
Biomedical subjects
P Labay
Publications and source records attributed to P Labay.
Ureteral function. IV. The urometrogram at increased urine output.
In this study the shape of the urometrogram or ureteral pressure pulse is evaluated as a function of urine output. Using a simultaneous monitoring technique, the urometrogram, spurt volume, and wave speed, as well as various aspects of wave geometry, have been studied on dogs with explanted bladders during various stages of urine output. The qualitative shape of the urometrogram is discussed for urine flows ranging from less than 0.01 ml per min to about 6 ml per min. An explanation of the shape of the urometrogram is presented and shown to be related to urine output and to length of the bolus. Preliminary experiments using mannitol, Lasix, Hypaque, and saline were all shown to induce similar changes in the shape of the urometrogram; however, the rate at which the changes occur was a function of the specific drug.
Animals↗
Current status of the urethral pressure profile as a urodynamic test.
The urethral pressure profile is a manipulation test of the bladder neck, urethra, and its sphincters. It measures the balance of pressure at each point along the urethra while a small amount of distending fluid is instilled continuously. The urethral pressure profile probably represents a perfusion pressure, a minimal distension pressure, or a minimal opening pressure that is altered by the caliber of the urethra and the compliance of its walls along its proximal course. The test is meaningful when each point along the traverse is compared, in succession, with all the other points and as long as the assumption holds that changes in bladder configuration, pressure, and filling are incosequential during performance of the test.
Humans↗
Computer evaluation of the effect of urecholine on the spontaneous activity of smooth muscle from the urinary bladder of the rabbit.
The spontaneous activity exhibited in vitro by smooth muscle strips from the urinary bladder of the rabbit under the influence of Urecholine in concentrations from 0.3 to 30 muM has been characterized in terms of three parameters: mean tension, frequency of contraction, and contractile deviation, all obtained by computer an alysis. While mean tension and frequency monotonically increased with concentration, the contractile deviation rose to a peak in the vicinity of 3.0 to 6.0 muM and thereafter decreased. At concentrations less than 10 muM the contractile patterns were almost periodic, while at 10 and 30 muM, the patterns became highly erratic. Histologic examination of a limited number of tissues showed longitudinally oriented muscle bundles with multiple anastomosing.
Animals↗