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Biomedical subjects

P Lanning

Publications and source records attributed to P Lanning.

At least 19 recordsLinked to original sources

Ultrasonic features of the congenital nephrotic syndrome of the Finnish type.

Ultrasonic features of the kidneys of seven infants with congenital nephrotic syndrome of the Finnish type under active conservative treatment are described. In all cases the kidney were enlarged an the cortex more echogenic than the liver and spleen parenchyma. The pyramids were small with hazy borders resulting in an indistinct or lost corticomedullary border. At follow-in the echogenity of the renal cortex increased still further in four infants and the pyramids became invisible. The differential diagnosis is discussed.

Diagnosis, Differential

The radiological evaluation of children with hypertension.

The value of radiological examinations in hypertension was analyzed in a series of 44 children. An i.v. urography had been performed in 43 cases with a pathological finding in 19 (44%). Renal angiography, employed in 19 cases, revealed abnormal findings in 12 (63%) patients. Micturating urethrocystography performed in 16 children gave no additional important information. The only complication noted was thrombosis of the femoral artery subsequent to renal angiography in one child less than one year of age. The diagnosis of hypertension based mainly on the i.v. urography in 12 cases but the renal angiography gave additional important information in 6 children. One child with obstructive hydronephrosis was also found to have a renal artery stenosis at renal arteriography. Based on these results, and particularly because secondary hypertension may frequently be treated surgically, we consider extensive radiological investigation with renal angiography is mandatory before receiving a final diagnosis of essential hypertension, and before starting long-term treatment.

Adolescent

Prediction of vesico-ureteral reflux in children from intravenous urography films.

Intravenous urography and voiding urethrocystography were performed on 255 children with urinary tract infection. Eighty-six (34%) of these children had some kind of abnormality of the urinary tract. Vesico-ureteral reflux was observed to 96 ureters (19%) in 69 children (27%). The prediction of vesico-ureteral reflux by two radiologists from urography films only gave 46 (48%) and 51 (53%) false negative results respectively. In cases of clinically important reflux (III--V degrees), however, the rate of false negative predictions was 0/18 and 1/18 (6%) respectively. The rate for false positive predictions were 45/413 (11%) for both radiologists. In view of the number of pathological findings in this series i.v. urography is recommended as a routine in children undergoing urological work-up after their first urinary tract infection. As the clinically important vesico-ureteral reflux seems to be predictable from urography films alone, voiding urethrocystography seems not to be justified in children with negative i.v. urography, and can be postponed and carried out later if the urinary tract infection recurs.

Adolescent

Venous drainage of the femoral neck in various stages of activity in Perthes' disease.

The venous drainage of the femoral neck in 73 children with Perthes' disease was analyzed from intraosseous venography films. 55 contralater symptomless hips were used as controls. In active stages of Perthes' disease, i.e. initial and fragmentation stage, the venous drainage was pathological in 46/55 hips (82%). In the restitution stage the finding was pathological in 7/18 (39%) and in healed Perthes' the venous drainage was normal in all six cases. Two out of the 55 symptomless hips showed pathological venous drainage. The disturbances in the venous drainage of the femoral neck seem to correlate with the stage of activity of Perthes' disease. Along with clinical and radiological signs of restitution the venous drainage seems to return to normal.

Adolescent

Comparison of ultrasound and roentgen examination of biliary tract.

The relative merits of gray-scale ultrasound and roentgen examinations of biliary tract diseases have been compared. Sonography was able to give a definite diagnosis in 74 of 95 roentgenologically unclear cases, and roentgen examination gave a diagnosis in 70 out of 105 cases unclear at sonography.

Biliary Tract Diseases

Lymphatic abnormalities in Noonan's syndrome.

Five boys who had Noonan's syndrome and lymphatic abnormalities are reported. The youngest boy had clinical lymphoedema and the other four showed dermal backflow after interdigital injection of Patent Blue indicating impairment of flow along the superficial lymphatics. One boy had severe bilateral chylothorax. The lymphographic findings in four of these boys are reported. Patients with the Noonan syndrome frequently have oedema of the hands and feet at birth, which decreases during the first years of life [10]. It has been demonstrated by lymphography that similar peripheral oedema in patients with the Turner's syndrome is due to lymphatic hypoplasia [1, 3]. We report certain lymphatic abnormalities diagnosed by lymphography in four out of five patients with Noonan's syndrome.

Adolescent

General lymphangiomatosis in a child.

The lymphographic findings in a 4 year old girl with general lymphangiomatosis are presented. The number of iliac and lumbar lymphatics had increased markedly and the lymph nodes were enlarged with very loose structure and with contrast medium distributed in scattered droplets and filiform channels.

Child, Preschool

Neonatal polycythemia and chest roentgenograms.

Chest roentgenograms of 34 newborns with a hematocrit of 75 or more at the age of 12 hours were studied. An analysis was made of the findings during the first four days of life and the results were compared with those of 18 newborns with a hematocrit of 65 or less. The cardiothoracic ratio (CTR) was found to be greater in the polycythemic infants than in the non-polycythemic infants, and greatest of all in infants with symptomatic polycythemia. Prominent pulmonary vascularity and pulmonary hyperaeration were seen more often in polycythemic newborns than in non-polycythemic infants. Eleven infants in the polycythemic group and three in the non-polycythemic group had some symptoms or signs.

Cardiomegaly