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P Lapalus

Publications and source records attributed to P Lapalus.

124 records · Page 7Linked to original sources
PubMedDate not supplied

[Comparative in vitro and in vivo study of several long-acting theophyllines].

This study describes the comparative in vitro and in vivo release of six slow-release formulations. In vitro, with half-change method, differences appear in the profiles, some formulations showing a linear release (Dilatrane, Euphylline LA, Théostat), the others an irregular release with 'plateau' related to the pH gradient (Armophylline, Cétraphylline, Théolair). In vivo, at steady state, the fluctuations are less important and the comparative kinetic study in ten normal healthy volunteers after chronic oral dosing of six different formulations show a slight variability in the theophylline release during 12 h. Great interindividual variations appear with all formulations. In fact, none of the formulations present an ideal release over a 12 h period.

Adult↗
PubMedDate not supplied

[Clinical significance of the erythro-plasmatic ratio of lithium (author's transl)].

Six hundred erythrocyte-plasma lithium ratios have been gathered from 67 patients presenting affective disorders. Ratios values in relapse period are not altered regarding those in remission phase as between periods with neuroleptic associations and those without. Ratios values are not noticeably modified by personality, sex and the evolution of affective disorders. But lithium preventive action is essentially found in patients with high erythrocyte-plasma.

Antipsychotic Agents↗