PubMed Health⌕ Search

Biomedical subjects

P Lazarov

Publications and source records attributed to P Lazarov.

8 recordsLinked to original sources
PubMed1976

Diagnostic value of chromosome examination in effusions from cancer patients.

Fifty nine effusions (6 from patients with benign diseases and 53 from cancer patients) were examined cytologically and cytogenetically. Only diploid cells were observed in the benign effusions. The majority of malignant effusions had chromosomal changes, but in three cases where cytologic examination had revealed the presence of malignant cells, only diploid metaphases were found. No false positive diagnoses were made either by the cytologic or by the cytogenetic technique. The concomitant use of cytologic and cytogenetic examinations has substantially improved the correctness of the diagnosis. If by cytologic examination 43 of the 53 effusions from cancer patients were diagnosed as positive, 4 as suspicious and 6 as negative, the combined results of the cytologic and cytogenetic examination can be summarized in 49 positive, 1 suspicious and 3 negative cases. The implications of these data for the medical practice are briefly discussed.

Breast Neoplasms↗
PubMedDate not supplied

[The contribution of the clinical examination to the diagnosis of bronchopulmonary cancer].

An analysis is made of the contribution of clinical examination to the diagnosis of primary bronchopulmonary cancer in a lot of 355 patients. As it is known bronchopulmonary cancer does not have a characteristic and patognomonic clinical symptomatology. In two thirds of the patients (236/66.4%) the disease' onset was marked by respiratory symptoms. In half of these patients (120/33.8% of the total number of cases) the respiratory syndromes for which the patient had requested medical help could have suggested the diagnosis, and were marked by a pseudo-pneumonia, or pneumopathy with long evolution, intensified coughing in a patient who had been coughing for a long time, or an onset marked by hemopthysis. In the other half of the patients in this group the onset symptoms had nothing characteristic. The onset marked by metastases was noted 69 of the patients (19.4%), and para-neoplastic syndromes were noted in 10 (2.8%). These certainly suggested the presence of pulmonary cancer. It appears that in over half of the patients 9195, or 54.1%) the clinical examination could suggest the existence of bronchopulmonary cancer, and this percentage increases if patients are included in those whose respiratory symptoms are not characteristic but in those which physical examination will evidence suggestive changes. Only in a very small number of patients (12, or 3.3%) the clinical examination did not provide any diagnostic element. These were the asymptomatic cases, accidentally identified in the course of a radiological examination. It should be stressed that the clinical suspicion of pulmonary cancer should always be confirmed by paraclinical investigations.

Adolescent↗