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Biomedical subjects

P Leconte

Publications and source records attributed to P Leconte.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Management of Meckel's diverticulum of fortuitous discovery].

A Meckel's diverticulum was discovered in 89 patients during routine exploration at the time of an appendicectomy. Subsequent treatment and complications of surgical correction of a Meckel's diverticulum are discussed. A different attitude appears necessary depending on whether the patient is a child or an adult : apart from some particular circumstances, a healthy diverticulum should be removed in children and left untouched in adults.

Adult↗
PubMed1983

Spontaneous electrodermal activity during sleep in man: an intranight study.

This study was designed to examine the intranight evolution of spontaneous electrodermal activity (EDA). Eight paid volunteer male students were recorded for 3 complete nights (after a habituation night). The results show that: during the first sleep cycle, EDA is significantly lower than during the rest of the night; rapid eye movement sleep evolves in a particular manner, which emphasizes the specificity of this sleep stage; and there is no internight habituation effect.

Adult↗
PubMed1981

Studies on the miscoding properties of 1,N6-ethenoadenine and 3,N4-ethenocytosine, DNA reaction products of vinyl chloride metabolites, during in vitro DNA synthesis.

1,N6-Ethenoadenine (epsilon A) and 3,N4-ethenocytosine (epsilon C) are formed when electrophilic vinyl chloride (VC) metabolites, chloroethylene oxide (CEO) or chloroacetaldehyde (CAA) react with adenine and cytosine residues in DNA. They were assayed for their miscoding properties in an in vitro system using Escherichia coli DNA polymerase I and synthetic templates prepared by reaction of poly(dA) and poly(dC) with increasing concentrations of CEO or CAA. Following the introduction of etheno groups, an increasing inhibition of DNA synthesis was observed. dGMP was misincorporated on CAA- or CEO-treated poly(dA) templates and dTMP was misincorporated on CAA- or CEO-treated poly(dC) templates, suggesting that epsilon A and epsilon C may miscode. The error rates augmented with the extent of reaction of CEO or CAA with the templates. Base-pairing models are proposed for the epsilon A.G. and epsilon C.T pairs. The potentially miscoding properties of epsilon A and epsilon C may explain why metabolically-activated VC and its reactive metabolites specifically induce base-pair substitution mutations in Salmonella typhimurium. Promutagenic lesions may represent one of the initial steps in VC- or CEO-induced carcinogenesis.

Acetaldehyde↗
PubMed1975

[An improved technique for transverse pelvic incisions: supra-pubian deinsertion of rectus abdominis (author's transl)].

Deinsertion of the rectus muscles allows an esthaetic supra-pubian transverse incision, enlargeable at will and yielding a solid repair. The technique has the same indications, and many more, as the Pfannenstiel incision. For those who keep on using the latter the present technique always enables the surgeon to transform a narrow field into a large transverse laporotomy.

Abdomen↗