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Biomedical subjects

P Leino

Publications and source records attributed to P Leino.

9 recordsLinked to original sources
PubMed2002

Carriers of the aspartylglucosaminuria genetic mutation and chronic arthritis.

OBJECTIVE: To ascertain whether being a carrier of an autosomal recessive disease, aspartylglucosaminuria (AGU), predisposes to chronic arthritis, as does AGU disease. METHODS: A group of 173 unrelated patients with rheumatoid arthritis (RA) but with no family members with AGU each gave a blood sample for AGUFin major mutation DNA analysis. A group of 131 AGU carriers who were parents of patients with AGU completed a questionnaire on joint symptoms and gave a blood sample for rheumatoid factor (RF) analysis. Eight RF positive parents with prolonged joint symptoms had a rheumatological evaluation. RESULTS: Six patients (1/28) with RA were carriers of the AGUFin major mutation, whereas the carrier frequency among Finns in general is 1/50 to 1/85. Three AGU carriers had chronic arthritis (2.3%), and 17 (13%) were RF positive; the respective percentages among Finns in general are 1.4% and 5%. CONCLUSION: As for AGU disease, carrier status may also predispose to chronic arthritis.

Adult↗
PubMed1989

Symptoms of stress predict musculoskeletal disorders.

STUDY OBJECTIVE: To determine whether there is a relationship between musculoskeletal disorders and presumed symptoms of stress. DESIGN: Cross sectional and mixed longitudinal cohort study. Longitudinal data were collected at baseline (1973) and at re-examinations in 1978 and 1983. SETTING: Community based. PARTICIPANTS: Study sample was drawn from employees who had worked for at least 15 months at government owned Valmet metal factories in Finland, and comprised 902 men and women out of a total eligible population of 2653; 74% of the women and 63% of the men took part in both re-examinations. MEASUREMENTS AND MAIN RESULTS: Musculoskeletal disorders were measured as rheumatic symptoms, clinical findings and presence of chronic specific diseases. Eighteen symptoms of stress were combined in a stress symptoms score. Stress symptoms were associated with rheumatic symptoms and clinical findings in all sex/occupational class groups at first examination (baseline); and the prevalence of chronic musculoskeletal disease was associated with stress symptoms in men and in blue collar women (skilled and semiskilled workers). The mean stress symptom score of 1973 and 1978 predicted the level of rheumatic symptoms and clinical findings in 1983, allowing for the relevant score at baseline. The mean score also predicted the incidence of disease during the second half of the follow up in women and in blue collar men. Rheumatic symptoms covaried with the stress symptoms. Change in stress symptoms was predicted by indices of musculoskeletal disorders. CONCLUSIONS: The results suggest that stress symptoms and musculoskeletal disorders are reciprocally related.

Age Factors↗
PubMed1988

Occupational class, physical workload, and musculoskeletal morbidity in the engineering industry.

In 1973, 502 employees in three metal industry plants, stratified by age, sex, and occupational class, were examined for physical workload by interview and observation at the workplace and for musculoskeletal disorders by questionnaire, interview, and clinical examination. Five years later, 88% of the sample were re-examined for their musculoskeletal status. The work of the blue collar groups was heavier as measured by indices of physical work load based on the observation and interview (physical strain, physical load, static phases, and stereotypy). Rheumatic symptoms, clinical findings in the musculoskeletal system, and chronic musculoskeletal diseases were more frequent in both female and male blue collar workers than in the respective white collar groups on the first occasion and the increase in morbidity during follow up was higher in the blue collar groups. At an individual level within the blue collar class, however, associations between indices of physical workload and musculoskeletal morbidity were weak or non-existent. The associations were weakened by selective movement of people with musculoskeletal disorders from heavy jobs to premature retirement or to lighter jobs. Physical strain and physical load were negatively associated with the incidence of long term musculoskeletal disorders in the female blue collar group.

Bone Diseases↗
PubMed1987

Trunk muscle function and low back disorders: a ten-year follow-up study.

Low back disorders and trunk muscle function were studied by questionnaire, interview, clinical examination, and performance tests in 902 employees in the metal industry. The survey was repeated after a 10-yr interval for 654 persons. For those who were allowed to participate in the muscle function tests, the prevalences of clinical findings in the low back and of chronic lumbosacral disease were inversely associated with muscle function in both cross-sectional studies. This association seems not to be explained by the interference of pain with muscle function tests. There was no association between muscle function at baseline and either the 10-yr incidence of chronic low back disease or the development of low back symptoms. Men with poor muscle function at baseline had a slightly elevated risk for the appearance of clinical findings at follow-up. There was an inverse association between the clinical findings at baseline and muscle function at follow-up. The association between low back disorder and trunk muscle function seems to result from an effect of the former on the latter, but poor muscle function may also contribute to the risk of disorder.

Back Pain↗
PubMed1985

Overweight and musculoskeletal morbidity: a ten-year follow-up.

The association of relative weight with various indices of musculoskeletal morbidity was studied in 902 Finnish white-collar and blue-collar workers. Data were collected in the years 1973 and 1983 through a postal questionnaire, by medical examination, and clinical assessment of the condition of the musculoskeletal system. In the overweight group (relative weight greater than or equal to 120 percent), higher mean levels in all musculoskeletal scores (the Musculoskeletal Symptoms Score, the Upper/Lower Extremities Score, the Low Back Score and the Musculoskeletal Findings Score) were observed, compared with the normal weight group. There was no evidence, however of rheumatic complaints in weight-bearing joints being more common in overweight individuals, contrary to the 'wear and tear' hypothesis. In a 10-year follow-up the changes in the musculoskeletal scores were analysed by stepwise multiple regression. Baseline relative weight explained 6.3 percent of the variation in the score based on clinical assessment. Neither baseline weight nor weight change were significant predictors of change in the other scores. No association was observed between overweight and lumbosacral disorders either in the cross-sectional study or in the 10-year follow-up.

Adult↗