Biomedical subjects

P Lespinasse

Publications and source records attributed to P Lespinasse.

4 recordsLinked to original sources

PubMed1992

Is polyurethane lead insulation still controversial?

A controversy arose some 10 years ago over the reliability of polyurethane lead insulation. On the basis of one of the longest standing and largest databanks worldwide, the authors compare the cumulative survival of several thousand polyurethane, standard silastic, and high-performance silastic electrodes as it pertains to the failure criterion described as insulation degradation. With the possible exception of the Medtronic 6972 (Medtronic, Inc.) electrode, polyurethane electrodes have a 100% reliability at 84 months, which is similar to silastic electrodes.

Databases, Factual↗

PubMed1991

[Changes in erythrocyte deformability in Alzheimer's disease].

In a previous work we showed an alteration of erythrocyte filtration ability in patients with Alzheimer's disease according to their age and illness duration. This study has for aim to find a criteria of deformability that would be constant in all Alzheimer patients and would show a modification of red cell membranes. The erythrocyte filterability was studied in this present paper, in accord to Reid and Dormandy method using two values of depression (5 and 0 cm of water). These depressions correspond to the physiological values of blood pressure at the level of precapillary and capillary systems. The ratio between the result obtained at 5 cm and the result at 0 cm is constant in normal patient without organic disease and it is independent of age. At the opposite, this ratio increase very significantly in all Alzheimer patients, and this is not correlated to the initial value of filtrability. This ratio could be an index of the alteration of red cell membranes.

Adult↗

PubMed1975

[Long-term survival in persons with cardiac pacemakers. Study based on 1,159 patients, 499 with regression at 4-10 years].

Analysis of the long-term survival of pacemaker carriers showed a parallelism between two curves: that of the survival in patients treated with a pacemaker as from the second month, and that of a control group with the same age and physical structure. Treatment in the first few years was made problematical by defects in surgical technique: while in 17% of reoperations, the reason was straightforward substitution of the pacemaker owing to wear on the battery, 83% were the consequences of complications. Of these, 23% consisted of shifts in the intracavitary probe, electrode failures, or increase in the threshold. The frequency of infections due to implantation or reoperation was 7,4%, in certain cases with fatal outcome. Bearing in mind that mortality from Adam-Stokes disease was 50% prior to the introduction of pacemakers, it can be maintained that this therapy represents a considerable step forward in cardiology. Mortality was 27% in all patients submitted to implantation.

Adams-Stokes Syndrome↗

PubMed1975

[Survival time of patients with cardiac pacemakers (author's transl)].

A comparison between the life expectancy of patients with pacemakers and that of a control population of similar structure shows a parallel course, although originally, after a postoperative phase of 2 months, the mortality rate of the patients with pacemakers was higher. Today the results are considerably better. Implantation of pacemakers is one of the greatest cardiological advances in the last 10 years for the effective treatment and prevention of cardiac arrest in atrioventricular block. The significance of this type of therapy becomes understandable if the fact that the mortality of Adams-Stokes attacks used to be about 50% is taken into consideration. In France, about 5000 persons each year have Adams-Stokes attacks.

Adams-Stokes Syndrome↗