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Biomedical subjects

P Llancapi

Publications and source records attributed to P Llancapi.

4 recordsLinked to original sources

[Pellagra: diagnosis still valid].

Pellagra, caused by niacin deficiency, was described in 1730 by Casal in Spain and is specially frequent in alcoholics, subjects with malabsorption and mentally ill patients. We report three alcoholic patients (one female) aged 32, 57 and 26 years old, presenting with the typical desquamative and hyperpigmented lesions in exposed areas. One patient also had mental changes characterised by aggressiveness and clouding of consciousness. A diagnosis of pellagra was reached and treatment with nicotinic acid was started with good clinical response in all cases.

Adult↗

[Cutaneous metastases. Clinical pathological review].

Cutaneous metastases may be the first clinical manifestation of a visceral carcinoma, its incidence fluctuates between 0.7 and 9% of the carcinomas and normally indicate a dismal prognosis. The most frequent morphologies of cutaneous metastases are metastatic nodules, sclerotic forms that appear as infiltrated and stiff plates, the inflammatory variety that resembles an erysipelatous plate, mammary and extra-mammary Paget's disease that appear as erythematous erosive and crusty plates resembling dermatitis.

Humans↗

[Adult T-cell lymphoma and Reed-Sternberg cells. A clinical case].

Adult T-cell lymphoma (ATL) is a neoplastic disease associated in 80% of cases with HTLV-I (Human T Lymphotropic virus type I) infection. 1-2% of HTLV-I carriers may develop the disease during their lives. In our country, the prevalence of HTLV-I infection is about 1%. We report a 72 y.o. woman HTLV-I positive, confirmed by Western-Blot. presenting with massive adenopathies, cutaneous tumor involvement, acute course and showing Reed-Sternberg cells (RSCs) in lymph node biopsy. The response to chemotherapy was poor, with the patient dying seven months after diagnosis. ATL and Hodgkin's disease (HD) are discussed highlighting that RSCs are not pathognomonic of HD though in their absence such diagnosis can not be made. RSCs are found in other benign and malignant disorders and it is especially important to differentiate HD from the other processes in order to dispense the appropriate treatment. This is the first case of ATL with RSCs reported in Chile. Hence, in our country we suggest systematic determination of the presence of HTLV infection when histopathology is compatible with HD and Non Hodgkin Lymphoma.

Aged↗