PubMed Health⌕ Search

Biomedical subjects

P LoGerfo

Publications and source records attributed to P LoGerfo.

30 records · Page 2Linked to original sources
PubMed1981

Cutaneous T cell lymphoma: characterization by monoclonal antibodies.

Monoclonal antibodies to human T cells permit the characterization of the surface phenotype of cutaneous T cell lymphoma (CTCL). The majority of CTCL cells are reactive with OKT1 and OKT3 monoclonals, which identify peripheral T cells and mature thymocytes. The neoplastic cells also react with OKT4, which recognizes the inducer T cell subset; they are, however, unreactive with OKT5 monoclonal, which identifies cytotoxic/suppressor T cell subsets. These data are in agreement with previous functional studies demonstrating that CTCL is a neoplasm of inducer (helper) T cells.

Antibody Specificity↗
PubMed1980

Fine needle cytologic diagnosis of thyroid nodules. Review and report of 300 cases.

Three hundred patients with thyroid nodules were evaluated with fine needle biopsy and cytologic evaluation. Nineteen of 23 cancers were diagnosed by fine needle biopsy alone, for a yield of 83 percent. Four of 300 diagnoses (1 percent) were false-positive, and the evidence of neoplasm at operation was 68 percent. We believe that fine needle biopsy will greatly decrease the number of unnecessary thyroid resections.

Adenoma↗
PubMed1978

Coexistent parathyroid adenomas and thyroid carcinoma. Can radiation be blamed?

The coexistence of parathyroid adenomas and thyroid cancer in a substantial number of patients with primary hyperparathyroidism has led to speculation implicating ionizing radiation as a possible cause. Experience with a group of 40 individuals harboring both tumors was reviewed and evidence of roentgen ray exposure to the head and neck was found in only one of these patients. Association of parathyroid adenomas and thyroid carcinoma cannot be explained on the basis of prior irradiation to the neck.

Adenocarcinoma↗
PubMed1975

Effect of ascorbic acid on rectal polyps of patients with familial polyposis.

Evidence for dehydrogenation by fecal bacteria in the genesis of colon cancer suggested that an antioxidant might modify these mechanisms. Ascorbic acid, 3 Gm. daily, was given to five patients who had active rectal adenomatous polyp formation long after ileorectal anastomosis for familial polyposis. During a 4 to 13 month study, rectal polyps disappeared in two, regressed partially in two, and increased in one. Among three additional treated patients with rectal polyps, one had a reduction in polyps and two were unaffected.

Adolescent↗
PubMedDate not supplied

Direct detection and amplification of Helicobacter pylori ribosomal 16S gene segments from gastric endoscopic biopsies.

Helicobacter pylori is an organism thought to play an important causative role in gastritis and peptic ulcer diseases. We have designed an RNA dot blot assay for the detection of H. pylori, using as probe a synthetic oligonucleotide complementary to its 16S rRNA. We have also used oligonucleotide primers, complementary to conserved sequences within bacterial ribosomal 16S genes, to amplify a H. pylori ribosomal 16S DNA fragment via the polymerase chain reaction (PCR). After determining the DNA sequence of this amplified H. pylori fragment, primers were designed for specific PCR amplification of H. pylori ribosomal 16S DNA sequences. Samples from clinical endoscopic biopsies were PCR amplified with universal 16S ribosomal primers to detect the presence of bacteria and with H. pylori-specific primers to uniquely detect H. pylori. Finally, by comparing the H. pylori-specific PCR assay to commonly used diagnostic tests, we demonstrate that the molecular technique of PCR amplification shows promising applications for the clinical detection of H. pylori.

Base Sequence↗
PubMedDate not supplied

Colonic lymphoma as a cause of massive rectal bleeding in a cardiac transplant recipient.

Lower gastrointestinal hemorrhage in immunosuppressed transplant recipients is associated with significant morbidity and mortality. This hemorrhage is often massive and frequently due to ulceration of the colon by opportunistic organisms requiring early diagnosis and resection. We report a heart transplant recipient with massive rectal bleeding from an unsuspected lymphoproliferative lesion of the sigmoid colon treated successfully with prompt surgical resection and reduction of immunosuppression. Although lymphoproliferative lesions are common in transplant recipients, particularly in those immunosuppressed with cyclosporine, we believe massive rectal bleeding to be a unique presentation of such a lesion.

B-Lymphocytes↗