Biomedical subjects
Publications and source records attributed to P Locher.
This paper describes a noninvasive, relatively inexpensive, and simple to use system developed by the authors for monitoring the visual inspection behavior of someone free to select any viewing angle of an object by moving about it while at the same time being able to rotate it. A demonstration experiment verifies the potential of the system to study 3-D form perception.
Design-trained subjects sorted fourteen solid forms under either visual or haptic conditions into groups on the basis of perceived similarity of balance or along a balance continuum. After these tasks of coarse and fine discrimination, each form was rated on ten bipolar stimulus attributes. Multidimensional scaling and property-fitting analyses were performed on the results of four experiments to determine the combined contribution of stimulus attributes and level of discrimination on the visual and haptic percept of balance. A balance dimension emerged for both modalities, but only when subjects were inclined to attend globally to the structure of a form by the coarse-discrimination task. Results indicate that visual balance is a holistic property of forms which derives from the synthesis of physical stimulus information. For touch, subjects appear to have equated balance with a symmetric distribution of weight/shape about the central axis of a form. Findings are related to theoretical notions of balance.
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Tissue specimens of synovial membranes from patients with rheumatoid arthritis (RA) and non-inflammatory joint diseases were analyzed with a panel of monoclonal antibodies directed towards T-lymphocyte subsets and natural killer (NK) cells. In the RA group, mononuclear cell infiltrations in the synovium presented a distinguished pattern as compared to the non-RA group. Inflammatory synovial membranes displayed an increased level of cells recognized by the monoclonal antibodies OKT4 and OKT8, especially attributable to the broadened layer of synoviocytes and to the fibrous synovial tissue. No significant difference in the RA patients was observed with regard to the percentage of OKT4 and OKT8 positive cells in different investigated compartments of the synovium, e.g., diffuse inflamed synovial tissue, fibrous synovial tissue, and perivascular infiltrations. OKT4 and OKT8 positive staining was additionally observed on spindle-shaped cells present in the fibrous and diffuse inflamed synovium. OKT10 binding cells were located in the deeper layers of synoviocytes, in the inflamed synovial tissue, and in one case in perivascular areas, whereas HNK 1 positive cells were scattered in the fibrous synovial and perivascular cells, as well as in lymphocyte clusters of synovium in RA patients.
Utilizing monoclonal reagents directed towards antigens of the monocyte-macrophage lineage and Ia antigens, the tissue architecture of synovial membranes obtained from patients with non-inflammatory joint diseases and patients with rheumatoid arthritis was studied. Emphasis was placed on the localization of the type I, type II and type III synoviocytes that previously had been defined by their cell surface phenotype with regard to the expression of monocyte-macrophage lineage (M theta) and Ia antigens as well as by their phagocytic capacity or the ability to produce glycosaminoglycans. In patients with non-inflammatory joint diseases, cells with the M theta + Ia+ (type I) phenotype constituted the majority of synoviocytes immediately adjacent to the joint cavity; cells with this phenotype were also scattered in the subsynovial tissue and in the perivascular regions. The fibroblastoid type III cells defined by the absence of both M theta and Ia antigens formed the major cell population in the subsynovial tissue in this patient group. In patients with rheumatoid arthritis, the Ia+ M theta + cells were present in a characteristic double configuration forming an intensely positive layer adjacent to the intra-articular space followed by an Ia- M theta - layer that again was succeeded by an intensely Ia+ M theta + layer. Large numbers of synoviocytes bearing M theta + Ia+ antigens were also demonstrated in the diffusely inflamed subsynovial tissue, in the perivascular regions as well as around and within lymphoid infiltrates.(ABSTRACT TRUNCATED AT 250 WORDS)
36 patients with agranulocytosis among them 29 cancer patients were treated in a Life Island (LI) during totally 990 days and were studied for their psychological reactions. Another group of 9 patients among them 6 leukemia patients were treated in reverse isolation (RI) during 578 days. The psychological reactions of these patients were equally studied and were compared with those of the first group. Main reactions to the isolation in the LI were signs of deprivation, specially movement deprivation, as well as aggressive and regressive behaviour. The patients in RI showed on the other hand sensations of loneliness and boredom. To enter and to leave the LI was more important for the patients than the beginning and the end of RI. The isolation was never terminated for psychological reasons. The following factors are important for coping with the isolation; human bindings to doctors, nurses and relations, activities, music, religion as well as adequate information and an attitude of the patient himself which allows him to support the fact of the illness.