Complement fixation in diseased tissues. II. Fixation of guinea pig complement in renal lesions of systemic lupus erythematosus.
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Autoimmune Diseases↗
Biomedical subjects
P M BURKHOLDER
Publications and source records attributed to P M BURKHOLDER.
Asymptomatic primary systemic amyloidosis.
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Amyloidosis↗
Sectioning at room temperature of unfixed tissues, frozen in a gelatin matrix, for immunohistologic procedures.
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Gelatin↗
Studies on the antigenic properties of complement. II. Analysis of specific agglutinins against certain components of guinea pig complement fixed on sensitized sheep erythrocytes.
Sheep erythrocytes sensitized with amboceptor and persensitized thereafter with guinea pig complement are agglutinated by rabbit anti-guinea pig globulin and by immune sera obtained by injection of rabbits with fixed complement. In this agglutination neither C'1 nor C'2 takes part. Fixed C'4 acts as an agglutinogen. An additional agglutinogen, distinct from C'4, was found on persensitized cells. This additional agglutinogen appears to be distinct from hemolytically active C'3.
Agglutinins↗
Studies on the antigenic properties of complement. I. Demonstration of agglutinating antibodies against guinea pig complement fixed on sensitized sheep erythrocytes.
Evidence is presented to show that guinea pig complement fixed on sensitized sheep red cells acts as a specific agglutinogen. Agglutinating antibodies that react with cell-fixed complement can be produced by immunizing rabbits with a complex of stromata-amboceptor-complement or with guinea pig serum globulin. These agglutinins can be removed by precipitation with guinea pig serum. They are, therefore, distinct from immunoconglutinins.
Animals↗