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P M Biner

Publications and source records attributed to P M Biner.

2 recordsLinked to original sources

Attribute-treatment interaction research using nonexperimental data and the allocation average.

Attribute-treatment interaction (ATI) research attempts to answer the question, "Which treatment is best for whom?" Recent critical reviewers of ATI methodology have cited numerous pragmatic and methodological shortcomings of traditional experimental designs and argued that successful ATI research will require an alternative approach. This manuscript describes a purely correlational ATI method that addresses the more serious criticisms of experimental ATI research. This paper also presents use of the allocation average for ATI research that is either experimental or correlational in nature. The allocation average estimates the clinical utility of differential treatment assignment based on ATI data in terms of improved treatment outcomes. The proposed method is illustrated with hypothetical psychotherapy data and data from a recent educational study.

Data Collection↗

Effects of nicotine on two types of motor activity in rats.

Effects of injections of two doses of nicotine (o.2 and 0.4 mg/kg body wt) were tested on general activity (in a photocell chamber) and on locomotor activity (in an activity wheel) in male and female rats of two ages (40 and 90 days). Behavior was monitored under light and dark conditions at 15, 30, and 45 min post-injection over a period of 12 days. A general excitatory effect of nicotine was observed in the photocell chamber, with the high dosage greatly increasing activity for younger and female animals. In the activity wheel an initial depressant effect was observed followed by excitation at the lower dose. no evidence for tolerance or difference between light and dark test conditions was found.

Age Factors↗