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Biomedical subjects

P M Brooks

Publications and source records attributed to P M Brooks.

At least 19 recordsLinked to original sources
PubMed1995

New insights into osteoarthritis.

Not only has our understanding of cartilage structure, synthesis and breakdown increased over the last decade, but so have the possibilities for investigation and treatment of osteoarthritis. New strategies for investigation include ultrasound, magnetic resonance imaging, radionuclide scintigraphy, monitoring of biochemical markers for cartilage breakdown and miniarthroscopy. There is greater appreciation of the importance of exercise and analgesics in pain management, and drugs to retard cartilage breakdown are under development.

Diagnosis, Differential↗
PubMed1995

A 5-year follow-up of a controlled trial of an arthritis education programme.

A 5-yr follow-up of an arthritis education programme is reported. After adjustment for those lost, deceased or moved away, the 5-yr response rate was 75% among intervention subjects and 78% among controls. Individuals who participated in the education programme maintained their increased knowledge in some aspects. The relative difference in pain and disability over 5 yr was greater in the control group. Most individuals were less active at practising exercise after 5 yr. Improvement in performing exercise and joint protection shown at 12-months follow-up did not persist. Additional questions after 5 yr showed that participants in the education programme had significantly more contact with rheumatologists, physiotherapists and occupational therapists. The participants developed an increased internal sense of control of the disease between 12 months and 5 yr. There was also a significant reduction in reported problems with their disease after 12 months, maintained after 5 yr. This may indicate that patient education contributes to the patient's feeling of responsibility for, and ability to cope with, their diseases.

Arthritis↗
PubMed1995

Interactive conference voting. The OMERACT II Committee. Outcome Measures in Rheumatoid Arthritis Clinical Trial Conference.

We describe and analyze opinion polling results from interactive voting procedures undertaken before and after presentations during the Outcome Measures in Rheumatoid Arthritis Clinical Trials Conference (OMERACT II) in Ottawa, Canada, June 30-July 2, 1994. The scoring procedure was a matched voting design; when a participant used the same keypad at the beginning and end of voting, change within a participant could be estimated. Participants, experienced in the rheumatic diseases included clinicians, researchers, methodologists, regulators, and representatives of the pharmaceutical industry. Patients under consideration were those with any rheumatic diseases. Questions were constructed to evaluate the change in voting behavior expected from the content of the presentation. Statistically significant and substantively important changes were evident in most questions.

Arthritis, Rheumatoid↗
PubMed1994

Rheumatology.

Explore the source record for details and available documents.

Animals↗
PubMed1994

The psychosocial and clinical status of younger women with early rheumatoid arthritis: a longitudinal study with frequent measures.

A longitudinal study of 75 young women (median age 43 yr) with early RA was performed with psychological, clinical and functional status measured every 4 months for up to 44 months. The aim was to describe functional changes, and to estimate the association between psychosocial variables and function in the early years after diagnosis. Function was measured by the Stanford Health Assessment Questionnaire (HAQ) and improved on average by about 10% per year with most improvement occurring over the first year. Pain and psychosocial variables also improved over time. There was still a residual improvement in HAQ with time of about 4% per year not accounted for by changes in these measured variables. When examined over time, psychosocial variables were as important as disease and pain in determining function. The results suggest interventions based on the importance of maintaining social relationships could impact on function.

Adolescent↗
PubMed1994

Rheumatic manifestations of malignancy.

The rheumatic associations of cancer therapy are highlighted in this review. Interleukin-2, interferon alfa, and Calmette-Guérin bacillus immunotherapies are related to an inflammatory arthritis, and septic arthritis can complicate breast-cancer therapy. In a large retrospective study, an increased incidence of cancer in systemic sclerosis was confirmed, especially lung and breast cancers. Lymphoproliferative associations of Sjögren's syndrome were explored in a study of non-Hodgkin's lymphoma patients in which clinical and histologic criteria were used to diagnose Sjögren's syndrome. B- and T-cell lymphomas continue to be reported with rheumatologic manifestations such as seronegative polyarthritis and sacroiliitis. Malignant angioendotheliomatosis, which mimics central nervous system vasculitis diseases, has been reported. Paraneoplastic associations of lung, ovarian, and renal-cell carcinomas are discussed.

Arthritis↗
PubMed1994

Guidelines for use of antirheumatic drugs.

The Vth WHO/ILAR Task Force Meeting on Rhemuatic Diseases ratified guidelines for the use of antirheumatic drugs. Indications for use, contraindications, dose, administration and other usage principles, toxicity, and advice to patients have been agreed for analgesics, nonsteroidal antiinflammatory drugs, slower acting antirheumatic drugs, corticosteroids, and hypouricemic agents.

Adrenal Cortex Hormones↗