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Biomedical subjects

P M Fitzhardinge

Publications and source records attributed to P M Fitzhardinge.

28 records · Page 2Linked to original sources
PubMed1977

A comparative study of two developmental scales: the Bayley and the Griffiths.

50 high-risk infants consecutively selected from the population of a Neonatal Follow-up Clinic were tested using both the Bayley and the Griffiths Scales on the same day by the same psychologist without prior knowledge of the medical history. The mean age at testing was 13.1 mth with a range of 12--15 mth. Scores obtained from the Griffiths Scale were consistently higher than those obtained from either of the Bayley Scales (P less than 0.001). Intercorrelations between the Griffiths and the Bayley test were high at pH 0.01. These results suggest that, although the two tests may be used interchangeably, their numerical scores are not equivalent when administered at this age.

Child Development↗
PubMed1976

Mechanical ventilation of infants of less than 1,501 gm birth weight: Health, growth, and neurologic sequelae.

A two-year follow-up study of 73 low-birth-weight ( less than 1,501 gm) infants treated with positive pressure ventilation as neonates revealed the following: 24% incidence of lower respiratory tract infections during the first year; weight and height at two years averaging between tenth and twenty-fifth percentiles; major neurologic defects diagnosed in 14 boys (39%) and seven girls (18%) with one-year Bayley scores of less than 80. Major neurologic sequelae were closely associated with a neonatal history of seizures and intracranial hemorrhage and were more common in boys, survivors weighing more than 1,000 gm and following high-risk pregnancies.

Apnea↗
PubMed1976

Central nervous system patholgoy associated with mask ventilation in the very low birthweight infant: a new etiology for intracerebellar hemorrhages.

Mask-applied ventilatory support was noted to cause severe head molding in infants with birthweights under 1,501 gm. To determine if this molding was detrimental to the infant, the neonatal course and autopsy findings were reviewed for 106 infants. Twenty significant intracerebellar hemorrhages were found. An association between these hemorrhages and mask-applied positive pressure ventilation was demonstrated (P = .05). This relationship was maintained when all cases of generalized bleeding dyscrasia were removed (P = .021). It is proposed that the distortional forces produced by the mask attachment, together with the buffeting effect of intermittent positive-pressure ventilation, are causally related to the production of intracerebellar hemorrhages by direct contusion, by ischemic stasis, or by altered venous drainage. The authors urge strong caution when dealing with the small premature infant in using any attachment device that causes molding of the cranial vault, particularly in the occipital area.

Birth Weight↗
PubMed1975

Early growth and development in low-birthweight infants following treatment in an intensive care nursery.

Sixty-seven appropriate-for-date infants with gestations less than 33 weeks were followed for 12 months after their term dates. All had been born after September 1970. None received hypercaloric alimentation as neonates. Growth from the expected date of delivery was compared with that of 24 normal full-term infants and with accepted growth standards. The boys did not differ from the controls or the standard in mean weight, length, and head circumference, in weight and height indices, or in velocity of weight and linear growth. The girls had a slower velocity of weight growth for the first six months and had significantly lower weight indices at 12 months than did their controls. Velocity of linear growth, height indices, and mean length and head circumference for the girls were similar to those of the control standards. Gross central nervous system defects occurred in 22.5% of the boys but in none of the girls. More than one half of the abnormalities were hydrocephaly. The mean post-conceptional developmental quotient was 110 for the girls and 108 for the boys.

Asphyxia Neonatorum↗