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P M Goldfarb

Publications and source records attributed to P M Goldfarb.

12 recordsLinked to original sources
PubMed1999

Treated ovarian cancer: comparison of MR imaging with serum CA-125 level and physical examination--a longitudinal study.

PURPOSE: To evaluate whether gadolinium-enhanced magnetic resonance (MR) imaging can demonstrate clinically occult tumors in women with treated ovarian cancer and to compare the diagnostic accuracy of MR imaging, serum CA-125 (ovarian cancer antigen) level, and physical examination. MATERIALS AND METHODS: From 1992 to 1997, a longitudinal study comparing MR imaging findings, CA-125 values, and physical examination results with eventual clinical outcome in 69 women with treated ovarian cancer was performed. Tumor presence was determined with surgery, by an elevated CA-125 value, or with follow-up of patients longitudinally to assess for tumor recurrence. Absence of tumor was accepted with a disease-free interval of at least 2 years. RESULTS: Twenty-three of 39 patients in clinical remission with a normal CA-125 level and physical examination result had subclinical tumor proved at laparotomy or clinical follow-up. Gadolinium-enhanced MR imaging correctly demonstrated residual tumor in 20 of 23 patients. In all 69 patients, MR images had a 91% sensitivity, 87% specificity, 90% accuracy, and 72% negative predictive value and were superior to serum CA-125 level (53%, 94%, 63%, and 38%, respectively) (P < .001) and physical examination (26%, 94%, 43%, and 29%, respectively) (P < .001) in the depiction of residual tumor. CONCLUSION: Gadolinium-enhanced MR imaging is a valuable clinical tool in patients with ovarian cancer. An abnormal MR examination with a normal CA-125 value is a strong indication of residual or recurrent tumor.

CA-125 Antigen↗
PubMed1997

Physical therapy.

Explore the source record for details and available documents.

Health Services Misuse↗
PubMed1984

Adjuvant immunotherapy for melanoma.

Adjuvant immunotherapy was administered to 84 lymph-node-negative and 25 lymph-node-positive melanoma patients. This active specific homologous cell protein preparation was given after aggressive surgery and given over 2 years. Projected and observed survival rates are presented as well as other clinical and pathologic characteristics such as female-to-male ratio, site of primary, level and depth of invasion. The projected 5-year survival rates are 90% for all stage I with 89% for females and 94% for males. Lower extremity stage I projected 5-year survival rate was 88% for all, 87% for females, and 100% for males. The projected 5-year survival rate for stage II was 68% overall and 100% for lower extremity. Only two of five patients with an unknown primary have expired. All of these results are improved over expected survival. Hopefully a randomized prospective study will be stimulated to ascertain the basis for this improvement.

Aged↗
PubMed1981

Uterine sarcoma following adjuvant radiotherapy for rectal carcinoma.

Since adjuvant radiotherapy for rectosigmoid carcinoma appears to improve prognosis, the importance of delayed side effects such as radiation-induced malignant disease must be considered. The present report describes the first reported case of the development of a uterine carcinosarcoma more than 9 years after preoperative radiotherapy to the midpelvis for rectal carcinoma.

Adenocarcinoma↗
PubMed1980

Epidermoid carcinoma of the mouth and pharynx at Memorial Sloan-Kettering Cancer Center, 1965 to 1969.

One thousand thirty-four cases of epidermoid carcinoma of the mouth and pharynx were seen by the Head and Neck Service of Memorial Hospital during a recent 5 year period, 1965 to 1969. The 656 determinate cases previously untreated offer a clear basis for evaluation of the 5 year results of treatment, which as surgical in 90 percent of the cases. Preoperative radiotherapy was used in 130 cases. Preoperative radiotherapy was used in 130 cases, matched with 126 untreated cases. Etiologic factors are discussed. The presence and degree of lymph node metastasis are of paramount significance. Indications for elective treatment of the clinically negative neck are discussed in terms of anatomic, logistic and statistical principles. An analysis of failure point toward a continuing effort at combined therapy in this regional disease.

Carcinoma, Squamous Cell↗
PubMed1975

The immunologic responsiveness of regional lymphocytes in experimental cancer.

This report presents data showing that regional lymph node lymphocytes differ in their immunologic activity from distant lymphocytes and splenic lymphocytes during the initiation and progression of murine mammary adenocarcinoma. Three groups of 100 C3H/He J mice received subcutaneously 10-6 viable tumor cells (I), 10-3 tumor cells (II), or Millipore chambers containing 10-6 viable tumor cells (III). Lymphocytes from different areas in Groups I, II, III, and non-tumor-bearing controls were cultured with PHA-P, autologous tumor, or normal C3H/He J breast tissue. In all groups regional lymph node lymphocytes showed the earliest peak response to PHA-P and autologous tumor, while the splenic lymphocyte and distant lymphocyte responses were delayed, especially in Group III. These studies demonstrate the role of the regional lymph node in the initial processing of tumor antigenic information. The development of central immunity appears to be the result of dissemination of immunogenic tumor products. This may be mediated initially by the regional lymph node.

Adenocarcinoma↗
PubMedDate not supplied

Chronic venous access: bedside placement technique and complications.

Long-term tunneled venous access catheters have evolved into safe and useful tools. More than 80% of these are implanted in patients in operating rooms with fluoroscopic and anesthesia support. This article describes a technique for safely placing these catheters at the patient's bedside and focuses on how to identify, prevent, and manage common complications associated with this procedure. This article also summarizes 8 years of the authors' personal experience with bedside placement and describes a hospital quality assurance study that evaluated the efficacy of bedside placement. The role of appropriately trained personnel is highlighted. The possibility of cost savings, totaling millions of dollars, is raised.

Catheterization, Central Venous↗