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Biomedical subjects

P M Goodwin

Publications and source records attributed to P M Goodwin.

7 recordsLinked to original sources
PubMed1978

The effect of gamma radiation and neocarzinostatin on NAD and ATP levels in mouse leukaemia cells.

When mouse leukemia cells are treated with gamma-radiation or neocarzinostatin the intracellular NAD and ATP levels fall rapidly. We have shown that the ATP response is a consequence of the decreased NAD level. We suggest that this low NAD level results in decreased glycolytic activity and that there is a subsequent accumulation of phosphorylated sugars associated with the fall in ATP. Under these extreme conditions, therefore, the NAD level probably regulates the rate of glycolysis in cells which are utilising a rapidly metabolisable sugar as their energy source.

Adenosine Triphosphate↗
PubMed1976

[Effect of hormones on headaches in women and the associated endometrial patterns].

Headaches appear to be a reaction to changes in either exogenous levels. We are now investigating serum immunoglobulins in women with menstrual migraine and have found that in 22 women, 6 have low immunoglobulin A levels, all below the normal range, and 5 have high immunoglobulin M levels, above the normal range. The hereditary aspect of migraine may depend on inheriting a particular immune pattern which might cause a special sensitivity to hormone effects on blood vessels. This might account for the suppression of menstrual migraine by cortisone or large doses of progesterone. Deficiency of progesterone is unlikely to be responsible for the premenstrual syndrome as the week following menstruation is usually the time which is most often free from symptoms and at this part of the cycle there are very low levels of progesterone. The most reactive women are also the most sensitive to the side effects of drugs or hormones given to treat migraine, which makes the treatment of migraine difficult.

Adult↗
PubMed1976

The metabolic and hormonal response to glucagon. Part 1. Normal subjects.

Significant increases in mean plasma noradrenaline levels were observed 30-60 min and 150-180 min after a subcutaneous injection of 1 mg glucagon. The first peak coincided with the maximum blood glucose and plasma insulin levels and the second peak occurred after plasma growth hormone (GH) and cortisol levels had begun to rise. The first plasma noradrenaline peak may be important in inhibiting further insulin secretion. There was no evidence that glucagon stimulates adrenaline secretion in normal human subjects. It was also confirmed that there are significant increases in the levels of glucose, insulin, GH and cortisol and a significant decrease in FFA levels following subcutaneous injection of glucagon in normal human subjects.

Adult↗
PubMed1976

The metabolic and hormonal response to glucagon. Part 2. In patients with migraine.

The hormonal and metabolic changes following the subcutaneous injection of 1 mg glucagon have been studied in a group of 6 migraine patients, and the results indicate that the responses of these subjects differ from those of a control group. Three of the migraine subjects had raised basal plasma noradrenaline levels but all had been taking clonidine up to 12-24 hr before the test and the increased plasma noradrenaline levels were probably due to the effect of withdrawal of the drug.

Adult↗
PubMed1975

[The influence of hormones on headaches in women and the associated endometrial patterns (author's transl)].

Headaches appear to be a reaction to changes in either exogenous or endogenous levels. We are now investigating serum immunoglobulins in women with menstrual migraine and have found that in 22 women, 6 have low immunoglobulin A levels, all below the normal range, and 5 have high immunoglobulin M levels, above the normal range. The hereditary aspect of migraine may depend on inheriting a particular immune pattern which might cause a special sensitivity to hormone effects on blood vessels. This might account for the suppression of menstrual migraine by cortisone or large doses of progesterone. Deficiency of progesterone is unlikely to be responsible for the premenstrual syndrome as the week following menstruation is usually the time which is most often free from symptoms and at this part of the cycle there are very low levels of progesterone. The most reactive women are also the most sensitive to the side effects of drugs or hormones given to treat migraine, which makes the treatment of migraine difficult.

Adult↗