PubMed Health⌕ Search

Biomedical subjects

P M Hanno

Publications and source records attributed to P M Hanno.

9 recordsLinked to original sources
PubMed1979

The reproducibility and significance of carbon dioxide urethral profilometry.

Infusion urethral profilometry using carbon dioxide as a medium is an interesting study with a wide range of variability from day to day in a single individual, a fact that considerably reduces the value of a single measurement as a diagnostic tool. Presently, all forms of infusion profilometry must be considered to be interpretable only within the framework of the entire neurourologic evaluation. The study may be useful to make the clinician more secure about a particular diagnosis and as an objective measurement for medico-legal documentation. It also may be useful in predicting and objectively demonstrating treatment results if normal variability can be excluded. However, a high level of skepticism should be maintained regarding the value of the profile in those situations in which its interpretation does not correlate with the impression formed from the remainder of the neurourologic evaluation.

Adult↗
PubMed1978

Heparin as antibacterial agent in rabbit bladder.

Previous studies performed in our laboratory indicated that the primary antibacterial defense mechanism of the rabbit bladder is the antiadsorptive action of the surface mucopolysaccharide. The increased bacterial adsorption that occurs when the bladder is denuded of this layer was prevented by the instillation of heparin. Additional studies showed that the protective effect of heparin is inhibited by protamine, a further indication that the bladder's "antiadherence factor" is a mucopolysaccharide. Small amounts of heparin, applied directly to the mucoprotein-deficient bladder or to the surface of the inoculated bacteria, produced a statistically significant reduction in bacterial adsorption.

Adsorption↗
PubMed1978

The reproducibility and interpretation of carbon dioxide cystometry.

The day-to-day and same-day variability of carbon dioxide cystometry was examined in a population of men. Considerable variability was observed in each parameter monitored. The implications of such variability, and the validity and significance of certain cystometric events are discussed.

Adult↗
PubMed1978

Bladder surface mucin. Examination of possible mechanisms for its antibacterial effect.

We have previusly provided physiologic and histochemical data implicating the bladder surface mucin layer as an important new antibacterial defense mechanism. This mucin or its contents seems to act as an "antiadherence factor", inhibiting bacterial adherence to the bladder mucosa and thereby facilitating the removal of bacteria by the voiding process. The present study was designed to investigate three mechanisms by which the mucin might repel bacterial attachment. Our data suggest that neither IgA nor a chelating agent are anti-adherence factors. We did find, however, that pH had a significant effect on the adherence of bacteria to mucosal cells stripped of their mucin layer. This result suggest that electrochemical charge is important in bacterial adherence. We beleive that the mucin layer both provides an electrochemical coat on the bladder surface that is a poor substrate for bacterial adherence and blocks the receptor sites of the transitional cells to which the microbes might adhere.

Adhesiveness↗
PubMed1977

Management of simple ureterolithotomy closure.

Two methods of ureterotomy closure, loose adventitial closure and an unsutured incision, were evaluated and compared in 89 cases of simple ureterolithotomy. The loose adventitial closure was associated with a significantly shorter period of postoperative urinary drainage and a lower incidence of ureteral narrowing found at follow-up urographic examination.

Adolescent↗