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Biomedical subjects

P M Kilbridge

Publications and source records attributed to P M Kilbridge.

6 recordsLinked to original sources
PubMed2000

Developing a value-added Web site.

Once a healthcare organization has decided to establish a Web site on the Internet, it must next determine its implementation strategy, based on a full understanding of the goals of the site and the range of Web content and service offerings available in the marketplace. Although some organizations may choose to develop and maintain a Web site using exclusively in-house resources, most healthcare organizations will find that they can minimize the costs associated with this effort by making judicious use of outsourcing services. Whichever approach is used, it is important that financial managers charged with allocating resources for Web-site development and maintenance understand the implications, including relative financial impact, of key issues and options.

Advertising↗
PubMed1998

The role of information systems in IDS-physician relationships.

The success of integrated delivery systems (IDSs) depends on their ability to develop collaborative relationships with affiliated physician practices. As a long-term strategy, IDSs should develop sophisticated information systems that help their physician practices to effectively manage wellness and disease across the continuum of care. These information systems eventually should include a broad range of features, including systemwide access to communications technologies, such as e-mail and groupware, computer-based alerts and reminders to support wellness management, immediate access to hospital data from physician offices, and automated care guidelines. To address the immediate needs of affiliated physicians, however, IDSs should attempt to optimize the functionality of their existing communications systems, such as fax links and manual processes.

Computer Communication Networks↗
PubMed1994

Induction of intercellular adhesion molecule-1 and E-selectin mRNA in heart and skeletal muscle of pediatric patients undergoing cardiopulmonary bypass.

Leukocyte adhesion to vascular endothelium is an early step in inflammatory damage to tissues. To investigate the expression of endothelial adhesion molecules in the inflammatory response associated with cardiopulmonary bypass, we measured messenger ribonucleic acid (mRNA) encoding the adhesion molecules E-selectin and intercellular adhesion molecule-1 in intraoperative samples of cardiac tissue and skeletal muscle from infants undergoing cardiopulmonary bypass. Atrial tissue samples were obtained before and after bypass from 11 children and paired samples of rectus abdominis muscle from 15. mRNA was analyzed by ribonuclease protection with the use of nonmuscle actin as an internal control. Atrial E-selectin mRNA levels increased from before to after bypass (median increase 3.5-fold, p = 0.0002) in each of nine patients tested, and atrial intercellular adhesion molecule-1 mRNA increased in seven of nine patients (median, 2.1-fold, p = 0.025). In skeletal muscle, E-selectin mRNA increased in 11 of 12 patients (median 4.3-fold, p = 0.0018), and intercellular adhesion molecule-1 mRNA levels increased in 13 of 13 patients (median 3.2-fold, p = 0.013). E-selectin and intercellular adhesion molecule-1 induction in skeletal muscle occurred with or without circulatory arrest. We conclude that adhesion molecule mRNA induction occurs in cardiac and noncardiac tissue during cardiopulmonary bypass in man.

Cardiopulmonary Bypass↗
PubMed1988

Campylobacter pylori--associated gastritis and peptic ulcer disease in children.

Specimens obtained at gastric biopsies performed for suspected acid peptic disease in patients 5 through 17 years of age were retrospectively reviewed for the presence of Campylobacter pylori (CP), a gram-negative bacillus associated with chronic gastritis and peptic ulcer disease in adults. Of 98 patients who underwent antral biopsy (the most reliably colonized site in the stomach), 40 had chronic gastritis histologically. Of those 40 patients, 22 (55%) had CP present on the gastric surface. None of the 58 patients without gastritis present in biopsy specimens had CP. The gastritis in children with CP was more severe than in those without the organism: 86% of those with moderate gastritis and 92% of those with severe gastritis had CP. Eight patients with duodenal ulcers and one patient with a gastric ulcer had CP on biopsy. Among those patients without CP, only one had a duodenal ulcer and eight had gastric ulcers. An additional nine patients found to have CP on gastric fundic biopsy were identified, for a total of 31 patients with CP identified by either antral (22) or fundic (nine) biopsy. Initial resolution of symptoms with standard acid-antagonist therapy was noted in the 25 of 31 CP(+) patients so treated, but a high relapse rate was noted within one to two years in the patients who also had gastritis and duodenal ulcer. These findings support a strong association between CP colonization of the stomach and the presence of chronic gastritis and duodenal ulcer disease in children.

Adolescent↗