PubMed Health⌕ Search

Biomedical subjects

P M Krstenansky

Publications and source records attributed to P M Krstenansky.

7 recordsLinked to original sources
PubMed1993

Ketorolac injection use in a university hospital.

A drug-use evaluation (DUE) of ketorolac injection is described. Pharmacists at a 663-bed university hospital saved all new orders for ketorolac injection (except those from the operating, recovery, and emergency rooms) for five weeks. If an order was not in compliance with the DUE criteria, the DUE pharmacist contacted the prescriber to recommend a change. Fifty-two orders were evaluated. The daily dose exceeded that in the criteria in seven patients (13%). Conditions under which the product should be used with extra caution were present in eight patients (15%). Twelve patients (23%) received the drug for more than five days. Five patients (10%) had possible ketorolac-associated adverse effects. The pharmacist's concurrent interventions improved prescribing for correct dosage and facilitated discontinuation of the agent in high-risk patients. After follow-up educational efforts, a second audit in 28 patients showed further improvements in prescribing for correct dosage, but 25% of the patients received the drug for more than five days. No adverse effects were reported. A 72-hour automatic stop-order policy was implemented, and the fraction of patients receiving the drug for more than five days fell to 3% (of 223 pharmacy profiles reviewed). Three patients had apparent ketorolac-induced adverse effects. Educational efforts and adoption of a 72-hour stop-order policy decreased the duration of ketorolac injection therapy and the use of inappropriately large dosages and may have decreased the frequency of ketorolac-induced adverse effects.

Analgesics↗
PubMed1987

Astemizole: a long-acting, nonsedating antihistamine.

Astemizole is a long-acting, highly selective histamine1-receptor antagonist with minimal central and anticholinergic effects. Comparison studies have shown astemizole to be equal or superior to currently available antihistamines, beclomethasone nasal spray, and cromolyn sodium in relieving allergic symptoms of seasonal and perennial allergic rhinitis. Other uses include treatment of allergic conjunctivitis and chronic urticaria. Astemizole is not as effective for treatment of acute allergic symptoms because of its delayed onset of action. Astemizole and its active metabolite, desmethylastemizole, have long elimination half-lives permitting once-daily dosing. The incidence of sedation is lower than with conventional antihistamines, but increased appetite and weight gain do occur. Astemizole should be useful for both maintenance and prophylactic therapy in patients with chronic allergic conditions who cannot tolerate the sedative or anticholinergic effects of conventional antihistamines.

Animals↗