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Biomedical subjects

P M Margand

Publications and source records attributed to P M Margand.

5 recordsLinked to original sources
PubMed1977

Massive weight loss following jejunoileal bypass. I. Effects on pulmonary function.

Twelve morbidly obese patients had jejunoileal bypass surgery and serial detailed pulmonary function studies done over a one year period. Before operation they showed evidence of a decreased ventilation: perfusion ratio producing a "shuntlike effect" (Pao2 = 73, Paco2 = 37, pH = 7.44) while breathing room air (FIo2 = 0.209). They also had measurements consistent with pure restrictive lung disease. There was a highly significant improvement in the arterial oxygenation over the entire one year period and a significant loss of chest wall mass over the first 6 month period. The improved oxygenation most likely was due to a return of lung volumes toward normal and an improvement in the efficiency of the respiratory muscles.

Adolescent↗
PubMedDate not supplied

Short term abstinence from smoking: its place in preoperative preparation.

Newer pulmonary function instruments make measurement of small airway function possible as a routine, inexpensive part of preoperative preparation of patients with obstructive lung disease. Patients with early stages of chronic obstructive lung disease have maldistribution of ventilation and perfusion producing an increased A-a oxygen gradient. If the disease is at a reversible stage, early diagnosis and treatment should be helpful in preventing postoperative complications. Five volunteer heavy smokers stopped smoking for one week without any improvement in small airway function. A longer period of abstinence and other therapeutic modalities for these patients is needed prior to surgery to reduce the postoperative impact of this pathology.

Adult↗