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Biomedical subjects

P M McLoughlin

Publications and source records attributed to P M McLoughlin.

12 recordsLinked to original sources

Hyperplasia of the mandibular coronoid process: an analysis of 31 cases and a review of the literature.

PURPOSE: This study was undertaken to investigate the demographic and clinical features of mandibular coronoid hyperplasia and to assess the response to current treatments. PATIENTS AND METHOD: Case notes were studied and records made of age, sex, duration of symptoms, operative procedures, and response to treatment in all patients presenting at the Queen Victoria Hospital, East Grinstead, over a 20-year period from 1970 to 1990 with a confirmed diagnosis of mandibular coronoid hyperplasia. RESULTS: Thirty-one cases were recorded, 23 bilateral and 8 unilateral. The average age on presentation was 27.8 years for bilateral and 23.6 years for unilateral cases, with symptoms predating presentation by an average of 9 years and 6.75 years, respectively. Surgery was disappointing in terms of improving mouth opening. CONCLUSION: The results of this large series are supported by meta-analysis of the previous literature. They suggest that surgical management may be improved by a greater understanding of the pathogenesis of this condition.

Adolescent↗

Lateral open bite resulting from acute temporomandibular joint effusion.

Two cases of acute open bite, one arising from trauma to the mandible without actual fracture, and one from an acute episode of rheumatoid arthritis, are presented. The resultant malocclusions were due to a sudden increase of volume in the temporomandibular joint space with subsequent displacement of the mandibular condyle, following acute effusion.

Adult↗

Oncocytoma of the submandibular gland.

This report describes a case of oncocytoma, a rare, benign tumour which is particularly uncommon in the submandibular gland. The neoplasm was a chance finding in a gland which presented with recurrent swelling, assumed to be due to chronic sialadenitis.

Adenoma, Oxyphilic↗

Dermatofibrosarcoma protuberans of the scalp.

Dermatofibrosarcoma protuberans is an uncommon tumour of the dermis and rarely occurs on the scalp; there are few known predisposing factors. A case is described of such a tumour that occurred at the site of radiotherapy for a basal cell carcinoma. Histological characteristics, behaviour and management of dermatofibrosarcoma protuberans are discussed.

Aged↗

Post-endodontic pericoronitis.

Pericoronitis is defined as inflammation of the soft tissue around the crown of any partially erupted tooth. A case of pericoronitis with an unusual aetiology is described.

Adult↗

Odontogenic myxoma: an orthodontic presentation.

A maxillary odontogenic myxoma in a 17-year-old male was diagnosed as a result of his presenting to an orthodontist. Histological diagnosis was obtained following enucleation, and a further wide local excision performed as definitive treatment. The origin of the tumour was most likely from the follicular remnants of a previously exposed canine tooth.

Adolescent↗

Adriamycin effects on transplasma membrane redox functions in porcine neutrophils.

Transplasma membrane electron transport, as assayed by external ferricyanide reduction, has been related to control of growth and hormone response of cells. Elicitor-stimulated transmembrane NADPH oxidase is important for bacteriocidal superoxide production by neutrophils. Since adriamycin is myelosuppressive and can stimulate superoxide production, its effects on the two redox systems of porcine neutrophil plasma membranes were compared. Adriamycin inhibits transplasma membrane ferricyanide and stimulates superoxide production activated by phorbol myristate acetate (PMA). Ferricyanide reduction in PMA-treated cells becomes resistant to inhibition by adriamycin. These results provide evidence for an independent effect of adriamycin on transmembrane ferricyanide reduction and on superoxide generation.

Animals↗