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Biomedical subjects

P M North

Publications and source records attributed to P M North.

6 recordsLinked to original sources

Lithium in the treatment of aggression in mentally handicapped patients. A double-blind trial.

In a double-blind trial lasting 4 months in 42 mentally handicapped patients, the effect of lithium on aggression was assessed in comparison with placebo. In the lithium-treated group, 73% of patients showed a reduction in aggression during treatment. There were significant differences in mean weekly aggression scores and in the frequency of aggressive episodes between the lithium and placebo groups. Side-effects were noted in 36% of the lithium group (and 20% of the placebo group), but were mainly transitory. There were no episodes of toxicity, and no patients had to be withdrawn from the trial. Lithium appears to be worth a 2-month trial in such patients, where repeated aggression has not been relieved by more appropriate placement, occupation or company.

Adult↗

A model for avian lung ventilation, and the effect of accelerating stimulation in Japanese quail embryos.

A simple stages model is proposed for the interval between the start of lung ventilation and the start of clicking in Japanese quail embryos. The model is extended to describe the effect of accelerating stimuli and is fitted to data sets from three different experiments. We see that the model provides a useful synthesis of the variety of results, and furnishes a framework for the analysis of further experiments.

Animals↗

Is routine episiotomy necessary?

One hundred and eighty one primigravid women delivering vaginally in July and August 1982 in the Rotunda Hospital, Dublin, were randomly allocated to one of two groups. Patients in one group were to undergo episiotomy. Those in the other group were not to undergo episiotomy unless it was considered to be essential. The outcome was compared with that of the clinical practice over the previous six months at the hospital. Of the 92 patients allocated not to undergo episiotomy, seven (8%) had one done for medical reasons compared with 507 (89%) in the previous six months. First degree tears occurred in 23 (25%) and second degree tears in 43 (47%). Nineteen (21%), however, retained an intact perineum compared with only 35 (6%) of the women who had delivered in the preceding six months. Assessments of perineal pain, bruising, swelling, and healing and records of ingestion of analgesics were made for the first four days after delivery, and again at a check up six weeks after delivery, in patients who had had spontaneous vertex deliveries. Forty patients who underwent episiotomy and 37 who sustained a second degree tear formed two comparable groups. There was no difference in outcome between them. Data were also evaluated for 19 women who retained an intact perineum, 22 who sustained a first degree tear, and 11 who underwent episiotomy and epidural anaesthesia; all 52 of these women had spontaneous vertex deliveries. Despite severe soft tissue injury in two patients those who fared best were those who retained an intact perineum. First degree tears were associated with symptoms similar to those associated with second degree tears. Those who fared worst were women who underwent episiotomy after epidural anaesthesia. The value of routine episiotomy in primigravid patients is questioned, but the final decision can be made only by the accoucheur at the time of imminent delivery.

Adolescent↗

A study of the transport and permeability properties of the guinea-pig amniotic membrane.

1. The simultaneous measurement of the two-way sodium flux across the in vitro amniotic epithelium did not reveal a preferential active movement of sodium in either direction. The amnion is thus unlikely to be the site of formation of amniotic fluid. 2. The permeability of the amniotic epithelium to some non-electrolytes has been measured with isotopes and was found to be generally low in relation to the thinness of the tissue. The permeability to non-electroytes would appear to be depebility to sodium and to non-electrolytes was found to vary with gestational age. The amnion from animals of 61-70 days' gestation was markedly more permanent than those at 50-60 days (term 70 days).

Acetamides↗