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Biomedical subjects

P M Olsen

Publications and source records attributed to P M Olsen.

5 recordsLinked to original sources

[Congenital bilateral perisylvian syndrome].

The congenital bilateral perisylvian syndrome is characterized by pseudobulbar palsy, moderate delay in mental and motor development and epilepsy. Three characteristic case stories are presented. Epileptic seizures are most frequently generalized: tonic, astatic, atypical absences and tonic-clonic seizures. Partial seizures are less frequent. Seizure control is often unsatisfactory. Neuroimaging demonstrates thickening of the cerebral cortex in the perisylvian area bilaterally; these changes together with the clinical picture establish the diagnosis. The etiology is unknown.

Abnormalities, Multiple↗

[Medication errors in a pediatric department].

In a prospective study, iatrogenic medication errors were registered among paediatric admissions. The two most common causes of incidents were neglecting to give a medication on schedule and administration of an incorrect dose-but extra dose errors, errors of omission, wrong rate errors and administration of unauthorized drugs also occurred. After implementation of a satellite pharmacy, medication error rates were compared, and a reduction of the more serious and potentially harmful incidents was shown.

Denmark↗

[Varying clinical pictures among young children with influenza virus type A infections].

The clinical course of Influenza type A virus infections in 47 hospitalized children aged 0-9 years was assessed retrospectively. The infection was diagnosed by demonstration of the virus in the nasopharyngeal secretion during the acute phase of the illness. Out of 21 Influenza A strains in which the subtype was determined, one was found to be H1- and 20 were H3-subtype. Lower respiratory tract disease was the main diagnosis in 21 children, 16 of whom had pneumonia; 14 of these patients were under three years of age. Gastro-intestinal symptoms occurred in 40% of the children over three years of age. Eight patients had febrile convulsions, a girl aged nine years had double vision and vertigo and a female infant aged two months had periodic apnoea and bradycardia. The reasons for hospitalization were febrile convulsions, abdominal pain, lower respiratory tract symptoms and high pyrexia.

Child↗

Rupture of the knee capsule from articular hyperpressure. Experiments in cadaver knees.

We used 10 cadaver knees to estimate the safe pressure during arthroscopy by measuring the volumes and pressures of irrigation fluid at different flexion angles. Maximum volumes could be contained at 35 degrees of flexion. Pressures of 200 to 450 mmHg were measured, and all the knees ruptured by extension or flexion after they were filled to 100 mmHg at 35 degrees of flexion. Fifty milliliters of irrigation fluid had to be removed if the pressure remained constant when extending from 35 degrees and 70 ml when flexing to 90 degrees. Totally, 100 ml irrigation fluid had to be removed when flexing from 35 degrees to 120 degrees. Our investigation indicates that a pressure of 150 mmHg can be tolerated by all knees. Both flexion and extension from the 35 degrees position must be done gently and slowly using a large bore, wide-open inflow and outflow tubes allowing egress of irrigation fluid to prevent capsular rupture, extravasation of irrigation fluid, vascular compromise, or compartment syndrome.

Arthroscopy↗