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Biomedical subjects

P M Pavliuk

Publications and source records attributed to P M Pavliuk.

16 recordsLinked to original sources
PubMedDate not supplied

[Serum glucose-6-phosphatase activity in thyrotoxicosis patients both fasting and following a sugar load].

A study was made of the activity of glucose-6-phosphatase in the blood serum of patients with thyrotoxicosis and in healthy persons and of its change after glucose loading. The activity of the enzyme on fasting stomach proved to be increased in the patients with throtoxicosis. The activity of the enzyme remained unchanged in these persons after glucose loading both during the hyperglycemic and the hypoglycemic phases of the glycemic curve; it remained high till the end of the observation period. In healthy persons, during the hypoglycemic phase of the glycemic curve, the activity of the enzyme was doubled, and at the height of hyperglycemia, after glucose loading- it was no different from the initial value. It is supposed that a high activity of the enzyme in the patients with thyrotoxicosis was associated with reduction in glycogen content in the tissues, along with activation of the glycogenolysis and gluconeongenesis processes.

Fasting↗
PubMedDate not supplied

[Certain indicators of carbohydrate metabolism and functional state of the islands of Langerhans in thyrotoxicosis].

The character of the sugar curves, blood insulin activity and the activity of glucose-6-phosphatase was studied in patients with thyrotoxicosis. It was revealed that thyrotoxicosis was accompanied by an increase in Bodwen's hyperglycemic coefficient with the normal values of Rafalsky's and Sokolnikov's coefficients. In this disease blood insulin activity was elevated, and the response of the insular apparatus to hyperglycemia considerably exceeded such in the control. The blood serum activity of glucoso-6-phosphatase was also elevated and failed to change in different glycemia levels. The mentioned indices increased considerably with the aggravation of the disease.

Blood Glucose↗
PubMedDate not supplied

[Current theories on the mechanism of the effect of glucagon on carbohydrate metabolism].

Glucagon is considered for mechanisms of its action on the carbon metabolism, its significance in the complex polyhormonal regulation of the glucose synthesis and metabolism being studied. Glucagon exerts its effect on cells through specific receptors arranged on the plasma membrane, while its effect on the carbohydrate metabolism is mediated, mainly, by cAMP-dependent phosphorylation os some proteins participating in regulation of carbohydrate synthesis and metabolism including the proteins controlling expression of many genes. The glucagon effect on the level and efficiency of the action of insulin and some other hormones is an important link in the glucagon action on the carbohydrate metabolism.

Carbohydrate Metabolism↗
PubMedDate not supplied

[Disordered glucose tolerance in diffuse toxic goiter].

The paper is concerned with clinical analysis of 1856 case records of patients with diffuse toxic goiter (DTG) to determine the frequency of development of diabetes mellitus in this pathology. In order to study glucose homeostasis and pancreatic beta-cell function, the blood levels of glucose and IRI were investigated in 107 DTG patients (in decompensation stage) on an empty stomach and 30, 60 and 120 min. after glucose testing. Diabetes mellitus was noted in 8.6% of the DTG patients, i. e. thrice as more frequent as in the general population. Glucose tolerance disorders were revealed more than in a half of the patients (in 55% of the examinees), 19% of them had latent or evident diabetes mellitus. Pathogenesis of glucose homeostatic disorders was closely associated with function of the insular apparatus. Relative and then absolute insufficiency of beta-cells with respective changes develop gradually against a background of their elevated function at the onset of disease. The frequency and a degree of glucose tolerance disorders and beta-cell dysfunction were in direct relation to the gravity of a clinical course of DTG.

Adolescent↗
PubMedDate not supplied

[Insulinemia dynamics in thyrotoxicosis].

It was detected that the blood immunoreactive insulin (IRI) level in thyrotoxic patients is changed on an empty stomach and after glucose load and the pancreatic beta-cell response to hyperglycemia is raised. The IRI level decreases depending on the disease severity, but remains sufficiently high in comparison with that of the control, hypersensitivity of the insular apparatus to glucose being persisted. Subtotal strumectomy-produced euthyrosis, developed shortly after elimination of thyroid intoxication, promotes normalization of the phonic insulin blood activity, but hypersensitivity of beta-cells to glucose persists, being accompanied by arising prolonged hyperinsulinemia in these patients after glucose load.

Adult↗