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Biomedical subjects

P M Spalding

Publications and source records attributed to P M Spalding.

10 recordsLinked to original sources

Realities of craniofacial growth modification.

Facial growth modification can be an effective method of resolving skeletal discrepancies. There still is much controversy regarding our understanding of the nature and extent of skeletal orthopedic change possible in individual patients and the most effective appliances and timing of such treatment. In the treatment of class II patients, growth modification can lead to an improvement, if not complete correction of the class II malocclusion. Although two-phase treatment with an early first prepubertal phase can be effective, a later single-phase approach during early puberty seems to be equally effective. Certainly, before surgical correction of the mild to moderate skeletal class II problem in a growing patient is considered, an orthopedic phase of treatment prior to the pubertal growth spurt is an appropriate first step. Skeletal class III patients with a maxillary deficiency stand to gain significant benefits from early orthopedic treatment. However, such therapy may produce more favorable changes for older children and adolescents than previously thought. Nevertheless, orthopedic correction of the mild to moderate skeletal class III should be accompanied by regular progress evaluations to avoid creating significant dental compensations in the face with little skeletal change that ultimately requires surgery anyway. Skeletal class III patients with mandibular excess and/or vertical excess are poor candidates for growth modification. Orthopedic palatal expansion appears to be effective and stable at any time prior to late puberty, a stage of development when ossification of the maxillary sutures is more advanced. Consequently, the timing for expansion may be better determined by the specific needs of each patient. A functional shift resulting from a crossbite is optimally corrected early, so that asymmetric growth of the mandible can be reduced or even prevented. Postpubertal orthopedic expansion is likely to result in bone bending, which will reverse itself over time, potentially leaving periodontal compromise of the maxillary posterior teeth. Therefore, surgically assisted expansion should be considered in such cases. Vertical maxillary excess is challenging to treat with growth modification. The combination of interocclusal acrylic bite blocks combined with a high-pull headgear presently appears to be the best means available. Unfortunately, this treatment has limited success, it must be continued over many years owing to the long-term nature of vertical growth, and it is counterproductive in achieving a balanced sagittal jaw relationship in class I or class III patients with vertical excess. Future research will permit us to have a greater understanding of the nature and extent of facial growth modification possible in individual patients and the optimal appliances and timing of treatment to achieve the best outcome. The development of intraoral osseointegrated attachments such as implants and onplants hold promise for a future means of dissipating orthopedic forces to prevent unwanted dentoalveolar changes that presently occur with our tooth-borne appliances. Analogous attachments presently are undergoing clinical testing for surgically assisted orthopedic movements associated with distraction osteogenesis.

Adolescent↗

The influence of growth hormone (rhGH) therapy on tooth formation in idiopathic short statured children.

The purpose of this preliminary study was to evaluate tooth formation in children with idiopathic short stature, before and during treatment with recombinant growth hormone (rhGH). Twenty-nine short-statured children ages 6 to 13 years were assigned into two treatment groups, an "experimental" group (n = 18), which received rhGH, and a "control" group (n = 11), which was observed for 1 year before commencing rhGH treatment. Clinical and radiographic records were obtained at the initial, year 1, and year 2 visits. Tooth formation and stature were assessed by calculating Z-scores, appropriate for the age and gender of each child. Delta-Z scores, which measure the change in Z-score over time, were also calculated between annual visits. Height was measured and recorded every 3 months, and Z-score statural norms for age and gender were derived from the 1977 National Center for Health Services national probability sampling. Tooth formation standards were derived from Moorrees et al. A matched control sample for tooth development was derived from untreated children. Tooth formation was initially delayed although the degree of reduction in stature exceeded the initial degree of delay in tooth formation. During this 2-year study, rhGH therapy had a significant influence on acceleration or gain in stature, but did not have a significant influence on tooth formation.

Adolescent↗

Orthodontic adjunctive treatment in fixed prosthodontics.

The purpose of this article has been to increase the restorative dentist's appreciation for the rationale justifying preprosthodontic orthodontic treatment. It has not been intended to identify all the specific indications for the use of orthodontic treatment to enhance prosthodontic treatment nor has it been intended as a reference to assist the restorative dentist in placing and using orthodontic appliances. Figure 12 illustrates a typical case in which the combination of orthodontic and prosthodontic treatment resulted in a more favorable outcome than prosthodontic treatment alone. When planning prosthodontic treatment, the dentist should embrace a dynamic view of tooth position and determine whether restorative treatment can be enhanced by tooth movement. Improved tooth position can eliminate potentially pathologic occlusion and create a healthier periodontal environment that is easier to maintain. In addition, it permits the dentist to place restorations that often require less natural tooth reduction during preparation, and that are more esthetic, functional, stable, and durable. Orthodontic treatment that accomplishes these benefits may be limited to a partial fixed appliance localized to one segment of an arch or require a more extensive fixed appliance. Much of this treatment can be accomplished by the interested restorative dentist. Addressing more comprehensive orthodontic problems in patients requiring prosthodontic care is best managed through a restorative dentist and orthodontist team approach to treatment.

Dental Stress Analysis↗

Sensitivity and specificity of diagnostic tests for impaired nasal respiration.

Diagnostic tests are imperfect and vary in their sensitivity and specificity. The degree of imprecision may be calculated to yield probability estimates of accuracy for both the positive and negative predictions of tests under various conditions. Such information enables clinicians to decide whether to accept or reject test results or the tests themselves. Two pilot studies are reported to establish the diagnostic potential of cephalometric measurements and nasal resistance values for the identification of upper airway impairment. A linear estimate of adenoid size and an area index of adenoid encroachment in the nasopharynx were evaluated as diagnostic tests for increased nasal resistance. The sensitivity of the tests was 31.8% and 18.2%, while specificity was calculated at 83.3% and 66.6%, respectively. In the second study, nasal resistance was evaluated as a test to identify persons whose respiratory mode was equal to or less than 75% nasal airflow. At a NRz value of 5.0 cm H2O per liter per second, the sensitivity of this test was 41.2% and the specificity was 84.0%; with the critical value of NRz at 3.5 H2O per liter per second, the sensitivity was 64.7% and the specificity was reduced to 60.0%. The results suggest that these tests are too imprecise for the reliable identification of either those who might benefit from treatment or those for whom treatment is unlikely to yield benefits.

Adenoids↗

The effects of maxillary surgery on nasal respiration.

Le Fort I osteotomies frequently involve impaction of the maxilla into the nasal cavity, potentially affecting nasal form. It has been speculated that a concomitant change in nasal function may occur. The purpose of this study was to determine if there is an association between maxillary position and nasal function and to evaluate the influence of Le Fort I surgery on nasal function. Presurgical and postsurgical nasal resistance and percent nasal respiration were compared in 36 patients. Results indicated a mean change in nasal resistance 1 year after surgery, but mean percent nasal respiration did not change significantly. No prediction could be made for any patient relative to the effect of maxillary surgery on the nasal function parameters. No consistent association could be found between the amount or direction of maxillary surgical movement or the position of the maxilla and nasal respiration.

Adolescent↗

External nasal morphology and respiratory function.

Clinicians have been known to characterize nasal respiratory function on the basis of subjective appraisal of external facial morphology. Certain nasal morphologic features have been assumed to be associated with impaired nasal function. The purpose of this study was to develop measures of anterior external nasal morphology and to determine whether any of these measures correlate with nasal function. Nasal casts were produced from impressions of 60 postpubertal white subjects from which four measures were made to characterize nasal morphology: (1) nasal base shape, (2) minimum nasal orifice width, (3) nasal orifice shape, and (4) nasal orifice area. Nasal function was evaluated by measuring nasal airway resistance by means of posterior rhinomanometry and by measuring the air respired nasally and orally by means of the simultaneous nasal and oral respirometric technique. No significant correlations were found between external nasal morphology and nasorespiratory function. These findings underscore the necessity of avoiding assumptions about breathing function on the basis of clinical appraisal of external nasal form.

Adolescent↗

Respiration characteristics in subjects diagnosed as having nasal obstruction.

The purpose of this study was to determine the respective oral and nasal contributions to total respiration in patients scheduled for surgical corrections of nasal obstruction. The effect of anterior nares expansion and/or nasal decongestant administration on the nasal component of breathing was also examined in these patients. Although variability among subjects was demonstrated in the ratio of nasal respiration to total respiration, 25% of the "nasally-obstructed" patients were 100% nasal breathers and no patient had a nasal component less than 18% of total respiration. Great variability existed among the patients in their response to nares expansion and/or decongestant administration. Collectively, they demonstrated no significant mean increase in nasal respiration with nares expansion alone. The patients demonstrated an increase with administration of the decongestant and with decongestant combined with nares expansion. The latter condition resulted in an increase that was greater than with decongestant alone. The implication of this study is that the traditional diagnostic terms "mouth breathing" or "nasal obstruction" are not useful. They do not describe the type, location, or severity of an obstruction or the relative contribution of the nose and mouth to respiration. Many patients who experience symptoms or have signs of nasal obstruction can functionally compensate to maintain 100% nasal breathing.

Adult↗

The effect of methodology on the determination of nasal resistance.

Confusion and controversy continue to characterize scientific understanding of the role that respiration plays in modifying growth. Identification of specific methods to provide valid measurement of nasorespiratory function can help clinicians to (1) make an informed judgment regarding postulated relationships between respiration and growth, (2) test the validity of a diagnosis of impaired nasal respiration or "mouth breathing," and (3) evaluate the efficacy of treatment for nasal obstruction. A method that has been frequently used to quantify nasorespiratory function is nasal resistance measurement or rhinomanometry. This investigation used a common form of this method, studying 25 adult subjects to examine the effect of a number of variables in methodology on nasal airway resistance values. Results indicate that resistance to nasally inspired air was not significantly different from resistance to nasally expired air. However, a significant difference in estimating resistance was found between airflow rates of 0.25 and 0.5 L/sec, with nasal resistance increasing at the higher flow rate. Determination of the method error indicated that the technique was reliable and accurate for the sample studied. It was found that both expansion of the anterior nares and use of a nasal decongestant spray produced a decrease in mean nasal resistance. The study emphasizes the need to standardize the method of determining nasal resistance in order to permit comparisons among studies, to obtain a more reliable estimate of resistance, and to identify the location of maximum constriction in the nasal airway.

Adult↗

The water, DNA, collagen and noncollagen protein contents in embryos after maternal administration of a teratogenic dose of phenytoin.

The growth of developing A/J mouse embryos was studied after maternal administration of phenytoin (Dilantin), an anticonvulsant drug. Wet weight, dry weight, protein and DNA contents of the embryos were quantitated 24 h after drug administration. Collagen content was investigated because of its importance in cellular differentiation. The wet and dry weight of embryos from phenytoin-treated mothers were 52.3 and 57.5%, respectively, of that of embryos of control mothers. DNA and protein contents were also decreased in embryos from phenytoin-treated mothers. Collagen represented only 0.07% of the protein present in day 11 control embryos, but was increased 4.9-fold in embryos from phenytoin-treated mothers in comparison to controls. These results suggest that phenytoin reduces overall embryonic growth but stimulates collagen synthesis.

Animals↗