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Biomedical subjects

P Málek

Publications and source records attributed to P Málek.

At least 19 recordsLinked to original sources
PubMed1990

[Academician Vilém Laufberger and the Czechoslovak Academy of Sciences].

Academician Vilém Laufberger participated in a significant way in the work of the Czechoslovak Academy of Sciences. He was one of its founders as a member of the preparatory commission for its establishment, an important official in its presidium, founder and director of one of its institutes and a permanent long-term critical observer and commentator of its activities. He greatly appreciated the steep rise of biomedical research at the beginnings of the Academy as a worthy development of the traditions of world reknown physiologists J. E. Purkynĕ and I. P. Pavlov. He evaluated favourably also its subsequent development. At the very beginning he drew attention to some shortcomings which during subsequent development influenced the activities of the Academy in an adverse way. Their elimination is a task for the present time.

Czechoslovakia↗
PubMed1986

Comparison of serum and coagulum antibiotic levels with respect to protected blood coagulum.

Serum and coagulum antibiotic levels have a parallel course. Coagulum antibiotic concentrations are more than ten times lower than serum concentrations. Therefore the optimal dosage of perioperative infusion should be high enough to establish steady state by means of sufficiently high serum levels. Antibiotics capable of attaining high serum levels and having a long half-life are best suited for the formation of effective antibiotic concentrations in blood coagulum. This is particularly true for cephalosporins and penicillins. Aminoglycoside antibiotics are not recommended for the formation of protected coagulum. "Ceftriaxon in the treatment of Severe bacterial infections".

Animals↗
PubMed1986

Effect of mercurascan on the contractility and excitability of dog papillary muscle in vitro.

The authors studied in 6 experimental series the effect of Mercurascan (2-hydromercurifluorescein and 4-hydroxymercurifluorescein) on isolated dog papillary muscle in vitro; they evaluated the magnitude and character of its electrically stimulated contractions. It was found that at concentration of 10(-3)M and 10(-4) M, Mercurascan (MSC) exerts a significant positive inotropic effect on papillary muscle. Incubation of the muscle in a medium containing MSC at the above-given concentrations significantly suppressed the positive inotropic and arrhythmogenic effect of adrenalin, added in an over-threshold dose into the nutrient medium.

Animals↗
PubMed1985

Indications and experimental preparatory studies for pancreas transplantation.

Clinical and experimental evidence support the metabolic aetiology of diabetic microangiopathy. This paves the way for its management by transplantation of endocrine pancreas. In an informative article, the authors attempts to conceptualize their position concerning indications for pancreas transplantation and offer a review of their own experimental studies, a prerequisite before actual clinical application.

Animals↗